Item | Criterion |
---|---|
Study population | |
   1. | Patients with radiographically confirmed osteoarthritis or selected according to American College of Rheumatology guidelines |
   2. | Age, gender, and body mass index reported and not statistically different between groups |
   3. | Efficacy assessed on a single anatomical joint (for example, knee) |
Trial design | |
   4. | Randomisation |
   5. | Placebo-controlled study |
   6. | Double-blind study |
   7. | Duration of at least 3 months |
   8. | Selection of a single primary endpoint before beginning of trial |
   9. | Sample size based on power calculation |
Analysis and data presentation | |
   10. | Data analysed according to the intention-to-treat principle |
   11. | Reported dropout rate not more than 25% |
   12. | Report of adverse effects |