Figure 1

The mammalian families of NF-κB and IκB polypeptides. Conserved domains and their primary functions are indicated. Ankyrins, ankyrin repeat domain (functions by binding and inhibiting RHDs; Bcl-3 and IκBζ are exceptions because they do not function as classical inhibitors of the NF-κB activity); dimeriz., dimerization domain; DNA, DNA binding; NF-κB, nuclear factor-κB; IκB, inhibitor of NF-κB; RHD, Rel homology domain; NLS, nuclear localization sequence; Transactivation, transactivating domain (functions at nuclear target sites).