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Table 3 Candidate gene polymorphisms associated with osteoarthritis

From: Genetic markers of osteoarticular disorders: facts and hopes

Genetic

 

Association

 

polymorphism

Phenotype

found?

Reference

VDR

Female knee OA

Yes

[42]

 

Knee OA (osteophytosis)

Yes

[41]

 

Female OA (hip replacement)

No

[50]

 

Hand, hip, knee OA

No

[51]

 

Idiopathic OA

No

[39]

COL2A1

PGOA/chondrodysplasia

Yes

[140]

 

Nodal GOA

No

[141]

 

GOA, finger joints OA

No

[24]

 

GOA

Yes

[45]

 

Female OA (hip replacement)

No

[50]

 

GOA

Yes

[46]

 

Knee OA (joint space narrowing)

Yes

[47]

COL1A1

Female OA (hip replacement)

No

[50]

 

Idiopathic female OA

Yes

[39]

ER a

GOA

Yes

[38]

 

Idiopathic OA

No

[39]

TGFB1

Spine OA (osteophytosis)

Yes

[48]

IGF-I

GOA

Yes

[44]

Aggrecan proteoglycan

Male bilateral hand OA

Yes

[49]

  1. OA = osteoarthritis; COL = collagen; ER = estrogen receptor; GOA = generalized osteoarthritis; IGF = insulin-like growth factor; PGOA = primary generalized osteoarthritis; TGF = transforming growth factor.
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Arthritis Research & Therapy

ISSN: 1478-6362

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