From: Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?
Lean (group 1) | Overweight (group 2) | Obese (group 3) | Comparison of groups | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | ∆15 wks | ∆30 wks | Baseline | ∆15 wks | ∆30 wks | Baseline | ∆15 wks | ∆30 wks | Groups | At baseline | Change after 15 weeks | Change after 30 weeks | |
Median (range) |
Median (range) P -value^{a} |
Median (range) P -value^{a} | Median (range) |
Median (range) P -value^{a} |
Median (range) P -value^{a} | Median (range) |
Median (range) P -value^{a} |
Median (range) P -value^{a} | P -value^{b} | P -value^{b} | P -value^{b} | ||
Adipo-nectin ng/ml | 18620.8 (5707.0 to 23038.0) |
783.3 (-3501.6 to 4270.7) | 488.5 (-1047.7 to 6069.1) | 4580.4 (2939.7 to 9634.0) |
400.0 (-438.0 to 1681.0) |
578.0 (-1764.5 to 1281.3) | 4745.5 (2864.9 to 5879.0) |
1011.3 (-382.6 to 3273.8) |
1206.9 (-1157.4 to 3811.5) | Lean vs overweight | 0.013 | 0.591 | 0.346 |
n = 9 |
P = 0.441 n = 9 |
P = 0.398 n = 7 | n = 26 |
P = 0.122 n = 25 |
P = 0.861 n = 25 | n = 13 |
P = 0.133 n = 13 |
P = 0.214 n = 9 | Lean vs obese | 0.003 | 0.794 | 1.000 | |
Leptin ng/ml | 16012.4 (10250.4 to 25627.3) |
2136.2 (-4133.4 to 5400.4) | -4455.8 (-10473.7 to 2250.7) | 27658.2 (19222.8 to 45504.1) |
1417.0 (-6055.4 to 6858.3) |
1760 (-9912.1 to 9778.1) | 45300.0 (34456.5 to 86307.4) |
5269.7 (-5534.8 to 9055.5) |
1446.4 (-3059.4 to 8129.1) | Lean vs overweight | 0.067 | 0.939 | 0.161 |
n = 9 |
P = 0.515 n = 9 |
P = 0.128 n = 7 | n = 26 |
P = 0.778 n = 25 |
P = 0.443 n = 25 | n = 13 |
P = 0.422 n = 13 |
P = 0.594 n = 9 | Lean vs obese | <0.001 | 0.471 | 0.142 | |
NPY pg/ml | 114.5 (86.6 to 624.6) |
19.0 (-10.7 to 98.5) | 6.7 | 122.8 (80.5 to 164.9) |
-7.7 (-27.4 to 31.3) | 9.0 (-8.2 to 27.3) | 113.7 (76.0 to 553.8) | 21.8 (1.3 to 225.0) | 44.4 (18.3 to 1272.7) | Lean vs overweight | 0.82 | 0.178 | 0.824 |
n = 4 |
P = 0.465 n = 4 |
P = 0.18 n = 2 | n = 16 |
P = 0.959 n = 16 |
P = 0.256 n = 15 | n = 6 |
P = 0.075 n = 6 |
P = 0.043 n = 5 | Lean vs obese | 0.914 | 0.762 | 0.095 | |
Resistin pg/ml | 14768.2 (12312.3 to 27191.5) |
927.7 (-3165.5 to 3897.5) |
1006.1 (-8555.9 to 4448.6) | 14419.1 (13786.6 to 16531.2) |
437.3 (-1698.2 to 2634.9) |
701.1 (-573.9 to 3872.6) | 14951.6 (12671.2 to 20016.0) |
1189.2 (-1110.2 to 2292.4) |
3110.7 (-534.1 to 4311.0) | Lean vs overweight | 0.67 | 1.000 | 0.789 |
n = 9 |
P = 0.678 n = 9 |
P = 1.000 n = 7 | n = 26 |
P = 0.465 n = 23 |
P = 0.051 n = 25 | n = 13 |
P = 0.221 n = 13 |
P = 0.214 n = 9 | Lean vs obese | 0.794 | 0.845 | 0.837 |