Anti-MDA5 autoantibody-positive | Anti-MDA5 autoantibody-negative | ||
---|---|---|---|
Muscle strength | |||
Median lowest ever recorded CMAS (IQR)a | 46 (38 to 52) | 40 (27 to 48) | |
Muscle histology | |||
Median biopsy score (IQR) (17)b | Inflammatory (0 to 12)c | 2 (2 to 4.8) | 7 (5.5 to 9.5) |
Vascular (0 to 3)c | 0 (0 to 0) | 1 (0 to 2) | |
Muscle fibre (0 to 10)c | 2 (1, 2) | 7 (4 to 9) | |
Connective tissue (0 to 2)c | 0 (0 to 0) | 1 (0 to 1) | |
Total (0 to 27) c | 4 (3.25 to 8.5) | 15 (12.5 to 21) | |
VAS severity (0 to 10) c | 2 (2) | 5 (3.6 to 8) |