Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

Table 5 **Impact of co-localized factors* present in the medial compartment at baseline on loss of joint space width and of cartilage volume at 36 months in the placebo group**

	Loss of joint space width and cartilage volume linked to addition of one co-localized factor	P -value
Joint space width loss
mm	0.31	0.0004
%	-11.58	<0.0001
MRI (%)
Global knee	-0.86	0.033
Femur	-0.53	0.239
Plateau	-1.97	0.007
Medial compartment	-2.22	0.0005
Medial femur	-1.95	0.002
Medial plateau	-2.93	0.006

P-values were assessed with analysis of covariance (ANCOVA) using the number of co-localized factors in the medial compartment at baseline as the dependent variable. Statistically significant P-values are in bold. *Co-localized factors: 0 = neither bone marrow lesions nor meniscal extrusion, 1 = either meniscal extrusion or bone marrow lesions, 2 = meniscal extrusion and bone marrow lesions. MRI, magnetic resonance imaging.

ISSN: 1478-6362