Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56dim natural killer cells

Table 1 Patient characteristics (cohort II and CD*)

Characteristic	Value
Patients with GPA, n	22
Men/women, n	14/8
GPA in remission, n (%)	12/22 (55 %)
Age in years, median (range)	55.5 (35–79)
Duration of remission in years (of inactive GPA), mean (range)	4.4 (1–20)
GPA non remission (active), n (%)	10/22 (45 %)
Age in years, median (range)	51.5 (33–64)
BVAS, mean (range)	4.5 (0–19)
Localized GPA (upper airways and ENT organs only), n (%)	4/22 (18 %)
Generalized GPA, n (%)	18/22 (82 %)
ANCA
Positive	17/22 (77 %)
Negative	3/22 (14 %)
Not determinable	2/28 (9 %)
Patients with CD, n	12
Men/women, n	3/9

GPA granulomatosis with polyangiitis, BVAS Birmingham vasculitis activity score, ENT ear, nose and throat, ANCA antineutrophil cytoplasmic antibody, CD* inactive systemic inflammatory control diseases other than GPA comprising systemic lupus erythematosus (n = 4), panarteriitis nodosa (n = 1), overlap connective tissue disease (n = 1), chronic inflammatory bowel disease (n = 1), CREST syndrome (n = 1), primary Sjögren’s syndrome (n = 1), polymyalgia rheumatica (n = 1) and giant cell arteriitis (n = 2)

ISSN: 1478-6362