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Table 3 Baseline characteristics of ACPA-negative RA patients per MBDA category

From: ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation

 

MBDA category

p value

< 30 (n = 17)

30–44 (n = 29)

> 44 (n = 95)

Age in years, mean (SD)

48 (16)

60 (13)

62 (14)

< 0.001

Female, n (%)

13 (76)

22 (76)

58 (61)

0.21

Symptom duration in weeks, median (IQR)

26 (8–41)

12 (4–25)

12 (5–22)

0.13

(Sub)acute symptom onset, n (%)

3 (20)

7 (26)

46 (52)

0.01

66-SJC, median (IQR)

3 (2–7)

6 (3–13)

9 (3–13)

0.08

68-TJC, median (IQR)

12 (9–19)

11 (5–21)

9 (4–17)

0.23

RF positivity, n (%)

7 (41)

9 (31)

33 (35)

0.78

ESR (mm/h), median (IQR)

9 (4–14)

14 (6–33)

33 (19–48)

< 0.001

CRP (µg/mL), median (IQR)

3 (3–3)

3 (3–4)

22 (11–44)

< 0.001

  1. Characteristics of ACPA-negative RA patients with low, moderate or high MBDA score were compared with one-way ANOVA, chi-square test and Kruskal-Wallis test, as appropriate
  2. Symptom duration, time between symptom onset and inclusion in cohort; (sub)acute symptom onset, prompt onset of symptoms (< 1 week); SD, standard deviation; IQR, interquartile range; SJC, 66-swollen joint count; TJC, 68-tender joint count; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; RF, rheumatoid factor; ACPA, anti-citrullinated protein antibodies; RA, rheumatoid arthritis; MBDA, multi-biomarker disease activity