Cytokine | HCs (n = 118) | AOSD (n = 70) | Sepsis (n = 18) | p value | ||
---|---|---|---|---|---|---|
AOSD vs. sepsis | Sepsis vs. HCs | AOSD vs. HCs | ||||
EOTAXIN (CCL11) | 137.5 (95.1–186.4) | 104.0 (66.0–134.0) | 123.4 (70.5–172.5) | 0.41 | 0.54 | 0.01 |
FGF-2 | 37.7 (21.2–58.1) | 48.7 (41.1–74.4) | 25.7 (11.1–34.1) | < 0.0001 | 0.0057 | < 0.0001 |
G-CSF | 8.2 (0.1–22.5) | 100.9 (50.5–173.6) | 124.1 (45.9–255.2) | 0.69 | < 0.0001 | < 0.0001 |
GM-CSF | 1.5 (0.1–6.7) | 13.1 (5.7–26.8) | 1.8 (0.1–3.2) | < 0.0001 | 0.41 | < 0.0001 |
GRO (CXCL1) | 978.1 (775.5–1237) | 1488 (1034–2383) | 697.2 (432.1–1449) | 0.027 | 0.25 | < 0.0001 |
IFN-γ | 4.7 (1.5–11.3) | 22.7 (7.5–60.2) | 12.5 (3.0–21.1) | 0.052 | 0.13 | < 0.0001 |
IL-17 | 1.9 (0.3–6.2) | 5.3 (0.9–18.5) | 0.13 (0.1–7.4) | 0.019 | 0.29 | 0.0002 |
IL-18 | N/A | 12,070 (6027–16,451) | 104.7 (75.1–382.1) | < 0.0001 | N/A | N/A |
IL-6 | 0.1 (0–0.1) | 31.7 (12.3–69.7) | 28.1 (0.7–100.5) | 0.55 | < 0.0001 | < 0.0001 |
IL-8 | 63.0 (28.3–108.3) | 30.5 (15.6–50.9) | 49.8 (35.7–56.7) | 0.96 | 0.44 | < 0.0001 |
IP-10 (CXCL10) | 277.9 (221.0–351.8) | 1406 (661.8–3806) | 2082 (542.3–4212) | 0.81 | < 0.0001 | < 0.0001 |
MCP-1 (CCL2) | 655.9 (530.5–838.7) | 790.8 (475–1675) | 1510 (811–3281) | 0.13 | 0.027 | 0.011 |
MDC (CCL2) | 848.95 (703.0–1008) | 668 (338.5–1013) | 352.3 (753.7–1013) | 0.14 | < 0.0001 | 0.0036 |
MIP-1a (CCL3) | 14.9 (0.1–29.4) | 14.2 (1.1–20.1) | 18.6 (3.4–35.3) | 0.37 | 0.51 | 0.42 |
MIP-1b (CCL4) | 59.6 (32.3–82.8) | 62.1 (39.6–86.2) | 40.3 (9.5–59.0) | 0.11 | 0.16 | 0.13 |
TNF-α | 12.6 (9.3–16.7) | 30.1 (18.1–68.2) | 26.9 (16.7–73.9) | 0.71 | < 0.0001 | < 0.0001 |
VEGF | 99.4 (31.9–208.5) | 333.3 (128.0–616.4) | 28.6 (0.1–151.2) | < 0.0001 | 0.083 | < 0.0001 |