Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Table 3 GO terms identified by both TWAS and mRNA expression profiles of osteoarthritis

GO term	P value for TWAS	P value for mRNA expression profile
GO:0005515 ~ protein binding	0.0003	3.42E−08
GO:0005737 ~ cytoplasm	0.0183	0.0048
GO:0070062 ~ extracellular exosome	0.0225	0.0001
GO:0016491 ~ oxidoreductase activity	0.0312	0.0259
GO:0071260 ~ cellular response to mechanical stimulus	0.0323	0.0053
GO:0055114 ~ oxidation-reduction process	0.0424	0.0294

Note: the candidate genes identified by TWAS and mRNA expression profiles were further analyzed by the Database for Annotation, Visualization and Integrated Discovery tool (https://david.ncifcrf.gov/) for GO enrichment analysis, respectively. The common GO terms were finally detected by comparing the significant GO terms identified for TWAS the mRNA expression profiles
GO gene ontology, mRNA messenger RNA, TWAS Transcriptome-Wide Association Study

ISSN: 1478-6362