Fig. 5
From: Urate-induced epigenetic modifications in myeloid cells
Differential DNA methylation in hyperuricemic versus normouricemic people. Principal component analysis of whole blood DNA methylation data, obtained using Illumina InfiniumMethylationEPIC BeadChips in whole blood of 26 people with hyperuricemia compared to 50 normouricemic individuals (A). Differentially methylated regions (DMRs) at the HLA-G locus (B) and average DNA methylation levels (beta values) for all CpG probes found within HLA-G (ticks on the x-axis represent individual probes and DNA chromosome position is indicated) (C). Transcription factors are known to bind at the highlighted DMR1 and DMR3 regions according to the transcription factor ChIP-seq clusters from ENCODE with factorbook motifs (D)