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Table 1 Baseline characteristics of the RTX-treated SLE and AAV patients

From: First exposure to rituximab is associated to high rate of anti-drug antibodies in systemic lupus erythematosus but not in ANCA-associated vasculitis

 

SLE (n = 66)

AAV (n = 22)

Clinical features

 Females (n, (%))

60 (90.9)

12 (54.5)

 Age (median (IQR))

36.3 (29.8–50.3)

62.0 (44.0–70.5)

 Disease duration (median (IQR))

7.9 (2.6–14.3)

1.5 (0–6.5)

Disease activity

 SLEDAI-2Ka (n = 65) (median (IQR))

12.0 (7.0–16.0)

–

 BVAS (n = 17) (median (IQR))

–

15.0 (10.5–22.5)

Rituximab treatment regimens

 375 mg/m2 × 4 weekly infusions (n, %)

38 (57.6)

5 (22.7)

 1 g 2 weeks apart (n, %)

24 (36.4)

13 (59.1)

 500 mg 2 weeks apart (n, %)

4 (6.1)

3 (13.6)

Concomitant treatments

 IV cyclophosphamide (n, %)

36 (54.5)

10 (45.4)

 IV 6-methylprednisolone (n, %)

37 (56.1)

4 (18.2)

  1. IQR Interquartile range, SLEDAI-2 K Systemic Lupus Erythematosus Disease Activity Index 2000, BVAS Birmingham Vasculitis Activity Index, IV Intravenous
  2. aOne patient (indication peripheral polyneuropathy) was excluded from the calculation