Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis

Table 3 ROC curve in each subset determined by univariate/multivariable logistic regression analysis

Variables (FMF vs. sepsis)	Sensitivity	Specificity	Accuracy	AUC	AIC	Cutoff value (pg/mL or predicted probability*)
GM-CSF	0.86	0.94	0.89	0.95	30.3	8.3
TNF-α	0.82	0.78	0.80	0.82	62.7	16.3
VEGF	0.90	0.75	0.82	0.83	54.3	67.1
GM-CSF + TNF-α	0.93	0.94	0.93	0.98	19.3	0.75*
GM-CSF + VEGF	0.86	0.94	0.89	0.94	32.3	0.61*
TNF-α + VEGF	0.93	0.83	0.89	0.91	42.4	0.55*

Bold indicates the minimum number of cytokines among the subsets. AIC Akaike’s information criterion; AUC area under the curve; GM-CSF granulocyte-macrophage colony-stimulating factor; TNF-α tumor necrosis factor-alpha; VEGF vascular endothelial growth factor

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