Table 1 Tissue engineering-based applications of IGF-1
From: Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
Growth factors | Scaffolds | Cells | Effect | References |
|---|---|---|---|---|
IGF-1/BMP-2 | Fibrin glue | Mesenchymal cells isolated from rib perichondrium | Infecting mesenchymal stem cells with the adenoviral vectors AdBMP-2 and AdIGF-1 to induce transparent cartilage repair | [16] |
IGF-1/TGF-β | Polyglycolic acid (PGA) scaffolds | Chondrocytes | The presence of IGF-1/TGF-β,or genetically modified chondrocytes overexpressing IGF-1 significantly improved osteochondral repair | |
IGF-1 | Type II collagen glycosaminoglycan (CG) scaffold | Adult articular chondrocytes | Continuous local overexpression of IGF-1 leads to enhanced cartilage formation | [49] |
IGF-1/BMP-2 | Bilayered oligo (poly(ethylene glycol) fumarate) (OPF) hydrogel composites | Mesenchymal stem cells | IGF-1 and BMP-2 can synergistically enhance the formation of subchondral bone, and the delivery of IGF-1 alone has a positive effect on the repair of osteochondral tissue |