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Table 1 The table shows an overview of cohort characteristics of healthy and diseased study participants, as well as the respective number of fecal and oral samples. It also shows the range of clinical measurements available for the diseased study participants. Clinical measures range from the concentration of C-reactive protein (CRP mg/l), percentage of monocytes, percentage of lymphocytes, percentage of basophils, percentage of eosinophils, percentage of neutrophils, thrombocytes (cells/nl), number of erythrocytes (cellsp/l), to AP (U/l, alkaline phosphatase), LDH (U/l, lactate dehydrogenase), calcium concentration (mmol/l), hematocrit, MCV (fl, mean cell volume), MCH (pg/cell, mean corpuscular hemoglobin), MCHC (g/dl, mean corpuscular hemoglobin concentration), hemoglobin concentration (g/dl; Hb), and BSR 1h (1 hour blood sedimentation rate). The table includes the normal physiological ranges of the respective clinical measures based on UKSH Clinical Chemistry Department and Oster [34]

From: Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis

Cohort

Category/variable

Normal range

Fecal

Oral

Ratio or mean

±SD

#NA

Ratio or mean

±SD

#NA

All

F/M

-

25/16

-

1

28/18

-

1

 

Healthy/CRMO

-

20/22

-

0

23/24

-

0

 

Age

-

12.307

3.315

1

12.485

3.325

2

Healthy

F/M

-

11/8

-

1

13/9

-

1

 

Age

-

12.271

3.419

1

12.658

3.474

2

CRMO

F/M

-

14/8

-

0

15/9

-

0

 

Relapse (Yes/No)

-

8/14

-

0

9/15

-

0

 

Age

-

12.340

3.302

0

12.334

3.256

0

 

NSAID (Yes/No)

-

13/9

-

0

14/10

-

0

 

Methylprednisolon (Yes/No)

-

10/12

-

0

12/12

-

0

 

Cox 2 (Yes/No)

-

14/8

-

0

15/9

-

0

 

Etanercept (Yes/No)

-

2/20

-

0

2/22

-

0

 

Cortison (Yes/No)

-

5/17

-

0

7/17

-

0

 

Sulfasalazin (Yes/No)

-

4/18

-

0

4/20

-

0

 

Bisphosphonate (Yes/No)

-

2/20

-

0

2/22

-

0

 

MTX (Yes/No)

-

1/21

-

0

2/22

-

0

Physiology

BSR (1h)b

7.00–12.00

34.524

19.717

1

34.682

19.256

2

(CRMO)

CRP (mg/l)a

< 5.00

16.382

18.892

0

15.646

18.248

0

 

Hemoglobin/Hb (g/dl)a

10.70–13.90

12.164

1.164

0

12.179

1.114

0

 

Erythrocytes (cells/pl)a

3.85–5.15

4.597

0.294

0

4.605

0.283

0

 

Hematocrit/Hktb

5.00–40.00

35.909

3.022

0

35.958

2.896

0

 

MCV (fl)a

74.00–89.00

77.273

4.590

0

77.292

4.408

0

 

MCH (pg/cell)a

24.50–31.00

26.510

1.727

1

26.470

1.655

1

 

MCHC (g/dl)a

31.00–36.00

33.957

1.464

1

33.939

1.398

1

 

Thrombocytes (cells/nl)a

200.00–445.00

343.909

66.273

0

344.792

65.939

0

 

Neutrophils (cells/ml) in %a

26.00–75.00

53.245

8.431

2

53.355

8.628

2

 

Eosinophils (cells/ml) in %a

0.50–5.50

2.860

1.979

2

2.795

1.933

2

 

Basophils (cells/ml) in %a

< 1.76

0.389

0.285

3

0.381

0.273

3

 

Lymphocytes (cells/ml) in %a

25.00–55.00

34.710

7.340

2

34.605

8.006

2

 

Monocytes (cells/ml) in %a

1.50–8.50

8.132

2.304

3

8.257

2.241

3

 

Calcium (mmol/l)a

2.20–2.70

2.395

0.062

2

2.392

0.059

2

 

AP (U/l)a

142.00–335.00

178.167

61.045

10

179.692

58.705

11

 

LDH (U/l)a

107.00–314.00

188.500

25.792

2

186.955

26.245

2

  1. aReference values/range based on the UKSH Clinical Chemistry Department
  2. bReference values/range based on Oster [34]