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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: PTH (1-34) enhances the therapeutic effect of bone marrow mesenchymal stem cell-derived exosomes by inhibiting proinflammatory cytokines expression on OA chondrocyte repair in vitro

Fig. 4

The effect of ExoBMSC and ExoPTH on OA chondrocyte apoptosis was determined by flow cytometry and Western blotting. A Cells were processed by flow cytometry using Annexin V-FITC/PI staining. The percentage of the Annexin V-positive population indicates apoptosis induction in each group. B Cell lysates were prepared and analyzed by Western blotting for Bax and Caspase-3. β-actin was used as a loading control. Band intensities were quantified by IPP and normalized to β-actin. Data are presented as the mean ± SD, *p < 0.05 versus the OA group. Ctrl, control; OA, osteoarthritis; ExoBMSC, exosomes derived from BMSCs; ExoPTH, exosomes derived from PTH-preconditioned BMSCs; BMSCs, bone marrow mesenchymal stem cells

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Arthritis Research & Therapy

ISSN: 1478-6362

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