Table 2 Summary statistics of clinical and laboratory outcome parameters at baseline and after w6, w12, w24 and w52

 Baseline

28

4.61 (2.65–6.49, 1.76)

 w6

28

3.80 (1.49–6.60, 1.88)

0.002

 w12

27

3.26 (1.39–6.65, 2.04)

< 0.001

 w24

27

3.20 (1.27–6.37, 1.81)

0.001

 w52

18

2.73 (1.22–4.85, 2.06)

< 0.001

 Baseline

28

7.00 (0–22, 8.75)

 w6

28

3.00 (0–22, 7.00)

0.009

 w12

28

4.00 (0–21, 5.00)

< 0.001

 w24

27

3.00 (0–17, 4.00)

0.001

 w52

18

2.00 (0–15, 3.50)

0.004

 Baseline

28

2.50 (0–9, 4.00)

 w6

28

2.00 (0–6, 2.00)

0.052

 w12

28

1.00 ((0–7, 3.00)

0.009

 w24

27

0.00 (0–6, 2.00)

0.005

 w52

18

0.00 (0–6, 1.75)

0.012

 Baseline

28

5.40 (0.30–52.00, 17.36)

 w6

27

4.00 (0.30–61.87, 11.85)

0.687

 w12

26

3.25 (0.30–28.90, 6.95)

0.091

 w24

25

2.30 (0.30–41.40, 5.50)

0.028

 w52

18

2.00 (0.20–98.70, 5.02)

0.156

 Baseline

28

27 (8–66, 21,00)

 w6

28

20 (4–52, 24,50

0.027

 w12

28

18 (6–56, 23.25)

0.059

 w24

27

21 (2–70, 25.50)

0.203

 w52

18

18 (2–54, 20.00)

0.177

 Baseline

28

6.00 (2.40–10.00, 3.00)

 w6

28

2.90 (0.00–8.50, 3.95)

0.003

 w12

28

4.20 (0.10–8.90, 3.00)

0.003

 w24

27

5.00 (0.30–9.00, 3.70)

0.112

 w52

18

2.95 (0–8.00, 3.63)

0.002

 Baseline

28

4.00 (1.9–8.50, 1.70)

 w6

28

3.00 (1.0–7.50, 2.00)

0.002

 w12

28

2.25 (1.0–8.00, 1.63)

0.001

 w24

27

2.00 (0.5–10.00, 2.25)

0.066

 w52

18

1.50 (0.0–6.00, 2.00)

0.014

 Baseline

28

30.00 (0–240, 63,75)

 w6

28

2.50 (0–120, 30.00))

0.003

 w12

28

7.50 (0–90, 33.75)

0.025

 w24

27

0.00 (0–120, 45.00)

0.042

 w52

18

0.00 (0–150, 12.50)

0.091