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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis

Fig. 1

Methods overview and percent sGAG loss across all donors. A. Grade 0–1 osteochondral plugs containing full-thickness cartilage and 4-5 mm of the underlying bone were harvested from the talus joints of seven adult human donors. Plugs were left untreated, treated with 100 nM Dex, subjected to a single impact mechanical injury and cultured with 25 ng/mL TNF-α, 50 ng/mL IL-6, and 250 ng/mL sIL-6R, or treated with injury, cytokines, and Dex for 3 weeks. B. Summed total percent sGAG loss from the tissue to the medium over 3 weeks across all donors. N, no treatment; D, Dex alone treatment; IC, injury and cytokine treatment; ICD, injury, cytokines, and Dex. Error bars represent standard deviation. Bar: p < 0.05, day 21

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