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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study

Fig. 3

Effusion-synovitis-related metabolites. Levels of metabolites between the low (effusion-synovitis score 0) and high (effusion-synovitis scores 1, 2, and 3) groups are compared by the Mann-Whitney U test. Levels of alanine (a), cystine (b), methionine (c), propionylcarnitine (d), and uric acid (e) in the high group are significantly higher than those of the lower group. The box and center line indicate the first quartile, median, and third quartile. The dots indicate the outliers. Partial least squares with rank order of group (PLS-ROG) results for metabolome data (e–g). The effusion-synovitis score (from 0 to 3) was set as the response variable. A scatter plot of the first and second PLS-ROG scores for the explanatory variable (f). A bar plot of the first PLS-ROG score for the response variable (g). Significant metabolites in the PLS-ROG analysis with effusion-synovitis scores (h). Metabolites that correlate with both the Kellgren-Lawrence grade and effusion-synovitis score are indicated with an asterisk (*)

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