Fig. 5From: Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosisCalpain inhibitor treatment in mouse of the bleomycin model of SSc. A C3H/He mice were subjected to either sham treatment (Control) or BLM (bleomycin model of SSc) and then treated with calpain inhibitor (PD150606; 3 mg/kg/day, i.p.) or PBS (vehicle) for 30 days. Skin and lung tissue sections where then assessed by H&E staining. Scale bars, 50 μm, magnification X200. B Skin thickness was quantified and expressed in µM. C Lung inflammatory scores were determined based on histopathological analysis as described in materials and methods. Data are mean ± SD. The test of Homogeneity of variance showed P > 0.1, AVONA test was applied. n = 7, * P < 0.05 in comparison to Sham group; # P < 0.05 in comparison to BLM + PD150606 groupBack to article page