Defining minimal detectable difference in echocardiographic measures of right ventricular function in systemic sclerosis

Table 3 Standard deviation and coefficient of variation of repeated echocardiographic measures by PAH status

Parameter	Standard deviation of repeated measures			Coefficient of variation (%)
Parameter	Total SSc population	Cohort 1 (SSc without PAH)	Cohort 2 (SSc with PAH)	Total SSc population	Cohort 1 (SSc without PAH)	Cohort 2 (SSc with PAH)
TAPSE, cm	0.02	0.01	0.02	0.9	0.6	1.1
FAC, %	11.2	9.1	13.4	21.3	17.0	27.1
Tissue Doppler S’	0.4	0.3	0.5	3.2	2.5	4.2
RVOT VTI, cm	0.8	1.0	0.7	6.0	7.0	5.0
Global RVLSS, %	1.9	2.6	1.1	9.7	11.7	6.6
RVSP, mmHg	14.3	5.3	24.2	38.0	19.6	48.6
TAPSE:PASP, mm/mmHg	0.01	0.02	0.003	1.7	2.2	0.6

Abbreviations: SSc systemic sclerosis, PAH pulmonary arterial hypertension, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, S’ Tissue Doppler-derived right ventricular systolic excursion velocity, RVOT right ventricular outflow tract, VTI velocity time integral, RVLSS right ventricular longitudinal systolic strain, RVSP right ventricular systolic pressure, PASP pulmonary artery systolic pressure

ISSN: 1478-6362