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Table 4 Intra- and inter-observer variability

From: Defining minimal detectable difference in echocardiographic measures of right ventricular function in systemic sclerosis

Parameter

Panel A: Intra-observer variability

Panel B: Inter-observer variability

Total SSc population

Cohort 1 (SSc without PAH)

Cohort 2 (SSc with PAH)

Total SSc population

Cohort 1 (SSc without PAH)

Cohort 2 (SSc with PAH)

ICC (95% CI)

ICC (95% CI)

ICC (95% CI)

ICC (95% CI)

ICC (95% CI)

ICC (95% CI)

TAPSE, cm

0.949 (0.903–0.973)**

0.891 (0.730–0.956)

0.970 (0.926–0.988)**

0.904 (0.871–0.949)**

0.767 (0.409–0.908)**

0.940 (0.848–0.976) **

FAC, %

0.947 (0.900–0.972)**

0.930 (0.816–0.973)

0.952 (0.880–0.981)**

0.854 (0.563–0.938)**

0.719 (0.121–0.899)**

0.891 (0.660–0.960) **

S’ wave, cm/s

0.903 (0.816–0.948)**

0.975 (0.937–0.990)

0.823 (0.552–0.930)**

0.975 (0.954–0.987)**

0.912 (0.777–0.965)**

0.980 (0.950–0.992) **

RVOT VTI, cm

0.941 (0.889–0.969)**

0.891 (0.722–0.957)

0.963 (0.900–0.986)**

0.873 (0.760–0.933)**

0.655 (0.143–0.863)*

0.940 (0.850–0.976) **

Global RVLSS, %

0.925 (0.692–0.982)**

0.967 (0.917–0.987)

0.950 (0.775–0.990)**

0.978 (0.959–0.989)**

0.938 (0.843–0.976)**

0.980 (0.949–0.992) **

RVSP, mmHg

0.994 (0.989–0.997)**

0.950 (0.950–0.992)

0.993 (0.983–0.997)**

0.990 (0.981–0.995)**

0.965 (0.912–0.986)**

0.986 (0.966–0.995) **

  1. Abbreviations: ICC intraclass coefficient correlation, CI confidence interval, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, S’ tissue Doppler-derived right ventricular systolic excursion velocity, RVOT right ventricular outflow tract, VTI velocity time integral, RVLSS right ventricular longitudinal systolic strain, RVSP right ventricular systolic pressure
  2. *P-value< 0.01
  3. **P-value< 0.001