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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation

Fig. 3

The antibiotics, MEPM and VCM, but not the anti-fungal agent AMPH-B, ameliorate DSS-induced peripheral SpA of SKG mice. a Experimental scheme of mouse treatment with oral antibiotics (MEPM (1 g/L)+VCM (0.5 g/L)) or the anti-fungal agent (AMPH-B (0.3 g/L)) and DSS. Agents were administered in their drinking water with 6% DMSO for 1 week, followed by regular water for 1 week. Then, 1% DSS was administered in their drinking water for 2 weeks, followed by regular water. Ten mice were used in each group. b The body weight change in each group over the experiment. c–f Arthritis incidence rates and scores, enthesitis incidence rates and scores were recorded every 2 weeks. Values are the mean ± standard error of the mean (SEM). g, h FCM analysis of IFN-γ (g) and IL-17A (h) positivity of splenic CD4+ T cells in SKG mice administered with DMSO and DMSO plus antibiotics (MEPM+VCM). Five mice per group were used. Statistical analyses were performed by using the Mann-Whitney U test (*P <0.05, **P <0.01)

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