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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training

Fig. 3

HIIT restores the decrease in myofibrillar force production in the skeletal muscle of EAM mice. A Representative original records of in vitro Ca2+-activated force in chemically skinned fibers of gastrocnemius muscles from control (CNT) and EAM mice with or without high-intensity interval training (HIIT). Fibers were exposed to solutions with progressively higher free Ca2+ concentration: pCa 6.4, 6.2, 6.0, 5.8, 5.6, 5.4, and 4.7. B Specific force-pCa relationships. Two-way repeated-measures ANOVA with Tukey post hoc test was performed. C Maximum Ca2+-activated force per cross-sectional area (Fmax). D pCa50 (pCa at half-maximum force). Data presented as the mean and SEM from 28 to 31 fibers per group. One-way ANOVA with Bonferroni post hoc test was performed. *P < 0.05 CNT vs EAM, #P < 0.05 EAM vs EAM + HIIT

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