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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Increased Wnt/β-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis

Fig. 1

Dietary magnesium deficiency aggravated DMM - induced articular cartilage damage. A Schematic representation of in vivo experimental protocols. B Representative images of Safranin O/Fast Green–stained sections of knee joints from sham and DMM-induced OA mice fed with diets containing different amounts of magnesium (500 mg/kg, 300 mg/kg, 100 mg/kg). The low magnesium groups presented with severe cartilage damage and less Safranin O staining. Magnified images of regions marked by black boxes. Scale bar: 100 μm. C, D The severity of articular cartilage damage of mice groups above was quantified with OARSI scoring. The maximum OARSI scores (the maximum score of four compartments) and summed scores (sum score of four compartments) were presented (n = 9). Data were expressed as the mean ± SD and analyzed by one-way ANOVA test. (*P< 0.05, **P< 0.01, ***P< 0.001, ****P< 0.0001)

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