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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

Fig. 2

XOI-based ULT effects on serum metabolomic pathway analysis. A Two-way repeated measures ANOVA identified 115 metabolites (89 decreased and 26 increased) significantly differing between baseline and 24 weeks ULT titration to target. A summary of the numbers of metabolites that achieved statistical significance (p ≤ 0.05), as well as those approaching significance (0.05 < p < 0.10), is shown. B, C Pathway analysis was conducted with the 105 metabolites (p < 0.1) significant at 12 weeks ULT (B) and with the 165 metabolites (p < 0.1) at 24 weeks (C). At 12 weeks ULT, pathways were significantly enriched with changes in the AA metabolism (arrows, B). However, at 24 weeks ULT, significant altered pathways were mostly related to FA and polyamine metabolism (arrows, C)

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