Table 1 miRNAs involved in senescence or OA
From: Senescence in osteoarthritis: from mechanism to potential treatment
miRNAs | Mainly target molecule or pathways | Effects | References |
|---|---|---|---|
miR-290 | Â | Promotes senescence in mouse embryo fibroblasts | Pitto et al. (2009) [146] |
miR-22 | CDK6, SIRT1, Sp1 mRNA | Induces cellular senescence and suppresses tumour | Xu et al. (2011) [147] |
miR-302, miR-512-3p miR-515-3p | p21 mRNA | Rescue Ras(G12V)-induced senescence | Borgdorff et al. (2010) [148] |
miR-302b | IRAK4 mRNA | Inhibits NF-κB pathways | Afonina et al. (2017) [141] |
miR-146a | TRAF6 mRNA | Inhibits NF-κB pathways | O'Connell et al. (2012) [142] |
miR-34a | SIRT1 mRNA | Inhibits chondrocyte proliferation, promotes senescence and apoptosis | Yan et al. (2016) [145] |
miR-204 | Â | Inhibits proteoglycan (PG) biosynthesis | Kang et al. (2019) [144] |
miR-140 | IGF1R and TLR4 in PI3K-AKT pathway and JAG1 and NUMBL in the Notch pathway | Inhibits chondrocyte senescence and attenuates early OA development | Si et al. (2020) [143] |
miR-126, miR-130a, miR-142, miR-21, miR-93 | Â | Are associated with ageing | Olivieri et al. (2017) [149] |