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Table 2 Univariable survival analysis

From: Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis

 

Univariable analysis

 

Cox Regression analysis

p-value

Exp(B)

  

 Tricuspid annular plane systolic excursion (TAPSE)

0.003

0.862

  

 Fractional area change

0.918

0.919

  

 TDI TV s

0.777

0.973

  

 Pulmonary arterial compliance

0.001

0.759

  

 Cardiac index at rest

0.314

0.707

  

 Cardiac index increase

0.001

0.654

  

 RV pulmonary vascular reserve (mPAP increase/CO increase)

0.049

1.006

  

 Cardiac index peak

0.001

0.672

  

 Systolic pulmonary arterial pressure (sPAP)

0.217

1.027

  

 TAPSE/sPAP

<0.0001

0.063

  

 Right ventricular function - normal vs. any impairment

<0.0001

0.205

  

Kaplan-Meier analysis (categorial parameters)

 

Multivariable analysis stepwise forward selection

RV function and reserve

  

p-value

Exp(B)

 Tricuspid annular plane systolic excursion <18 mm

0.001

   

 Right ventricular function - normal vs. any impairment

<0.0001

   

 Pulmonary arterial compliance <2 ml/mmHg

0.002

   

 Cardiac index increase <2 l/min/m2

<0.0001

   

 RV pulmonary vascular reserve ≥3 mmHg/(l/min) (literature)

<0.0001

   

 Cardiac index peak <5.5 l/min

0.001

   

TAPSE/sPAP ≤0.6 mm/mmHg

<0.0001

 

<0.0001

0.201

Known prognostic predictors

 Age ≥60 years

0.004

   

 DLCO ≤65% predicted

<0.0001

 

0.003

0.297

 Sex

0.554

   

 Type of systemic sclerosis

0.497

   

 Pulmonary fibrosis

0.034

   

 Pulmonary vascular resistance ≥2 Wood Units

0.002

   

Combination of independent prognostic predictors (Kaplan-Meier)

 DLCO ≤65% and TAPSE/sPAP

<0.0001

   
  1. TDI tissue Doppler imaging, TV tissue velocity, RV right ventricular, DLCO diffusion capacity of the lung for carbon monoxide