Univariable analysis | ||||
Cox Regression analysis | p-value | Exp(B) | ||
Tricuspid annular plane systolic excursion (TAPSE) | 0.003 | 0.862 | ||
Fractional area change | 0.918 | 0.919 | ||
TDI TV s | 0.777 | 0.973 | ||
Pulmonary arterial compliance | 0.001 | 0.759 | ||
Cardiac index at rest | 0.314 | 0.707 | ||
Cardiac index increase | 0.001 | 0.654 | ||
RV pulmonary vascular reserve (mPAP increase/CO increase) | 0.049 | 1.006 | ||
Cardiac index peak | 0.001 | 0.672 | ||
Systolic pulmonary arterial pressure (sPAP) | 0.217 | 1.027 | ||
TAPSE/sPAP | <0.0001 | 0.063 | ||
Right ventricular function - normal vs. any impairment | <0.0001 | 0.205 | ||
Kaplan-Meier analysis (categorial parameters) | Multivariable analysis stepwise forward selection | |||
RV function and reserve | p-value | Exp(B) | ||
Tricuspid annular plane systolic excursion <18 mm | 0.001 | |||
Right ventricular function - normal vs. any impairment | <0.0001 | |||
Pulmonary arterial compliance <2 ml/mmHg | 0.002 | |||
Cardiac index increase <2 l/min/m2 | <0.0001 | |||
RV pulmonary vascular reserve ≥3 mmHg/(l/min) (literature) | <0.0001 | |||
Cardiac index peak <5.5 l/min | 0.001 | |||
TAPSE/sPAP ≤0.6 mm/mmHg | <0.0001 | <0.0001 | 0.201 | |
Known prognostic predictors | ||||
Age ≥60 years | 0.004 | |||
DLCO ≤65% predicted | <0.0001 | 0.003 | 0.297 | |
Sex | 0.554 | |||
Type of systemic sclerosis | 0.497 | |||
Pulmonary fibrosis | 0.034 | |||
Pulmonary vascular resistance ≥2 Wood Units | 0.002 | |||
Combination of independent prognostic predictors (Kaplan-Meier) | ||||
DLCO ≤65% and TAPSE/sPAP | <0.0001 |