Skip to main content

Table 4 Univariable and multivariable associations of RA participant characteristics with baseline composite diastolic dysfunction*

From: Prospective changes in diastolic function in patients with rheumatoid arthritis

 

Univariable (n=158)

Multivariable (n=131)

Demographics (baseline)

OR

95% CI

p-value

OR

95% CI

p-value

Age, per year

1.09

1.05–1.12

<0.01

1.08

1.03–1.14

0.003

Male versus female

1.36

0.58–3.21

0.48

0.45

0.12–1.70

0.24

Race/ethnicity

White

REF

REF

    

Black

0.59

0.23–1.51

0.27

   

Hispanic

1

0.48–2.07

1.00

----

----

----

Other

0.40

0.071–2.24

0.30

   

BMI, per kg/m2

1.03

0.98–1.08

0.26

0.96

0.89–1.04

0.36

RA characteristics (baseline)

RA duration (square root), per year

1.25

1.02–1.52

0.031

1.19

0.90–1.57

0.23

Joint deformities (square root)

1.72

1.31–2.26

<0.01

----

----

----

CDAI (square root), per unit

1.24

1.01–1.53

0.037

1.39

1.02–1.90

0.034

DAS28CRP

1.29

1.01–1.65

0.0041

----

----

----

RF (baseline)

0: <15 (REF)

REF

REF

 

REF

REF

REF

1: 15–500

2.94

0.77–11.25

0.12

3.50

0.59–20.70

0.17

2: >500

4.44

0.94–21.00

0.060

4.44

0.58–33.88

0.15

CCP (baseline)

0: <15.6 (REF)

REF

REF

REF

   

1: 15.6–250

2.11

0.50–8.95

0.31

----

----

----

2: >250

2.1

0.50–8.73

0.31

   

Square root CRP, per mg/liter

1.24

0.95–1.61

0.11

----

----

----

Log IL-6, per mg/liter

1.19

0.90–1.58

0.21

0.88

0.58–1.33

0.54

Log BNP, per pg/mL

1.54

0.77–3.08

0.22

----

----

----

Log troponin-I, per pg/mL

1.84

1.32–2.56

<0.01

1.097

0.66–1.81

0.72

Log galectin-3 ng/mL

1.91

0.89–4.10

0.097

----

----

----

RA medication

NSAIDs

1.14

0.60–2.18

0.68

----

----

----

Prednisone

1.08

0.54–2.14

0.83

----

----

----

Leflunomide

4.48

1.18–16.98

0.027

7.18

1.19–43.4

0.032

Methotrexate

1.07

0.55–2.07

0.84

----

----

----

TNF inhibitor

0.94

0.47–1.89

0.86

----

----

----

Tocilizumab

0.59

0.053–6.68

0.67

----

----

----

CV risk factors (baseline)

Current smoker, yes versus no

1.24

0.44–3.50

0.68

----

----

----

Ever smoker, yes versus no

1.53

0.80–2.94

0.20

1.17

0.48–2.84

0.73

SBP (baseline), mm/Hg

1.03

1.01–1.05

0.003

1.00

0.98–1.03

0.71

Statin use, yes versus no

1.37

0.56–3.32

0.49

----

----

----

Total cholesterol, per mg/dL

1.00

0.99–1.01

0.62

----

----

----

LDL, per mg/dL

1.00

0.99–1.01

0.88

----

----

----

Square root HDL, per mg/dL

1.08

0.82–1.43

0.57

----

----

----

PET/CT cardiac measures (baseline)

CAC score>100

4.42

1.75–11.22

0.002

----

----

----

CAC score>300

5.63

1.52–20.8

0.010

6.76

0.73–62.23

0.091

Log mean myocardial SUV, per unit

1.52

0.83–2.77

0.17

----

----

----

Log max myocardial SUV, per unit

1.64

0.97–2.71

0.066

1.37

0.72–2.60

0.34

Myocardial flow reserve (MFR)

0.75

0.43–1.30

0.31

----

----

----

Prob>F

 

<0.001

Pseudo R-Squared

 

0.26

  1. *Baseline diastolic dysfunction defined as having ≥ 1 of E/e′, LAVI, or TR Vmax in top 25%