Levels of extracellular matrix metabolites are associated with changes in Ankylosing Spondylitis Disease Activity Score and MRI inflammation scores in patients with axial spondyloarthritis during TNF inhibitor therapy

Table 4 Correlation between the biomarkers, CRP, and total SPARCC score. Spearman’s correlation was performed between extracellular matrix metabolites and MRI scores. Spearman’s rho (ρ) and p-values are shown

Biomarker	SPARCC, baseline	SPARCC, week 22	SPARC, week 46
PRO-C1
ρ	0.086	− 0.318	− 0.285
p-value	0.542	0.021	0.050
PRO-C3
ρ	− 0.012	− 0.110	0.135
p-value	0.933	0.436	0.360
PRO-C4
ρ	0.279	0.317	0.216
p-value	0.043	0.021	0.144
PRO-C6
ρ	0.031	− 0.187	− 0.110
p-value	0.825	0.184	0.457
C3M
ρ	− 0.006	0.222	0.235
p-value	0.966	0.113	0.108
C4M
ρ	− 0.070	0.081	0.281
p-value	0.623	0.568	0.056
C6M
ρ	0.496	0.297	0.034
p-value	0.0002	0.031	0.818
C7M
ρ	0.130	0.379	0.319
p-value	0.355	0.005	0.029
C10C
ρ	0.018	0.112	0.170
p-value	0.897	0.425	0.255
CRPM
ρ	− 0.169	0.152	0.170
p-value	0.227	0.283	0.247
EL-NE
ρ	− 0.088	− 0.011	0.228
p-value	0.530	0.935	0.119
VICM
ρ	0.158	− 0.153	− 0.228
p-value	0.258	0.273	0.123
CRP
ρ	− 0.205	0.263	− 0.228
p-value	0.153	0.057	0.123

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