Fig. 2

Altered frequencies of B cell subsets in AOSD PBMC. a The frequencies of B cell subsets in the peripheral blood of the healthy controls (n = 40) and AOSD patients (n = 27). b The relative frequencies of three CD27⁺ B cell subsets in the total CD27⁺ B cells. c The frequencies of B cell subsets in the peripheral blood of the healthy controls (n = 40), active AOSD patients (n = 18), and inactive AOSD patients (n = 9). d t-SNE analyses of B cell subsets in healthy controls’ and AOSD patients’ peripheral blood. *P < 0.05, **P < 0.01, ***P < 0.001, and ns, no significance (unpaired t test, naïve B cells, UM B cells, SM B cells, CD27⁺ B cells, DN B cells, and B10 cells in a and b; Mann–Whitney U test, B cells, and plasmablasts in a; One-way ANOVA followed by uncorrected Fisher’s LSD test, naïve B cells, UM B cells, SM B cells, CD27⁺ B cells, DN B cells and B10 cells in c; Kruskal–Wallis H test followed by uncorrected Dunn’s test, B cells and plasmablasts in c)