Total (n = 38) | Non-VSP (n = 20) | VSP (n = 18) | p-value | |
---|---|---|---|---|
Age, years | 27.3 ± 10.7 | 30.8 ± 11.8 | 23.6 ± 8.4 | 0.040 |
Gender (female), n (%) | 35 (92.1) | 19 (95.0) | 16 (88.9) | 0.595 |
Disease duration, months | 12.9 (5.0–33.4) | 16.9 (6.4–94.1) | 9.0 (5.0–15.3) | 0.151 |
VSP period, months | 7.0 (5.8–10.8) | 7.3 (6.0–12.6) | 6.9 (5.6–9.2) | 0.745 |
Naïve, n (%) | 18 (47.3) | 8 (40.0) | 10 (55.6) | 0.338 |
Refractory/severe, n (%) | 9 (23.7)/29 (76.3) | 4 (20.0)/16 (80.0) | 5 (27.8)/13 (72.2) | 0.709 |
Hypertension, n (%) | 5 (13.2) | 4 (20.0) | 1 (5.6) | 0.344 |
Vascular types, n (%) | 0.389 | |||
I | 10 (26.3) | 5 (25.0) | 5 (27.8) | |
IIa | 4 (10.5) | 2 (10.0) | 2 (11.1) | |
IIb | 5 (13.2) | 1 (5.0) | 4 (22.2) | |
V | 19 (50) | 12 (60.0) | 7 (38.9) | |
Symptoms | ||||
Fever, n (%) | 4 (10.5) | 2 (10) | 2 (11.1) | 1.000 |
Amaurosis, n (%) | 4 (10.5) | 3 (15) | 1 (5.6) | 0.606 |
Neck pain, n (%) | 5 (13.2) | 3 (15) | 2 (11.1) | 1.000 |
Visual loss, n (%) | 5 (13.2) | 3 (15) | 2 (11.1) | 1.000 |
Thoracalgia, n (%) | 6 (15.8) | 3 (15) | 3 (16.7) | 1.000 |
Fatigue, n (%) | 8 (21.1) | 4 (20) | 4 (22.2) | 1.000 |
Signs | ||||
Pulselessness, n (%) | 11 (28.9) | 5 (25) | 6 (35.3) | 0.495 |
Vascular murmur, n (%) | 13 (34.2) | 3 (15) | 10 (58.8) | 0.008 |
Laboratory parameters | ||||
Hemoglobin, g/L | 112.3 ± 18.6 | 112.1 ± 23.0 | 112.6 ± 12.6 | 0.933 |
WBC, × 109/L | 8.9 ± 3.5 | 8.4 ± 3.8 | 9.5 ± 3.2 | 0.371 |
Platelet, × 109/L | 329.4 ± 108.9 | 294.4 ± 95.2 | 368.6 ± 112.4 | 0.039 |
ALT, U/L | 11.0 (8.0–19.0) | 12.4 ± 6.7 | 15.6 ± 9.9 | 0.255 |
Albumin, g/L | 42.0 (39.0–43.0) | 42.0 (39.0–46.0) | 42.0 (40.3–43.0) | 0.533 |
Globin, g/L | 29.29 ± 4.90 | 27.53 ± 4.48 | 31.38 ± 4.67 | 0.018 |
Creatinine, μmol/L | 54.0 (47.0–67.0) | 72.2 ± 52.9 | 53.9 ± 14.9 | 0.190 |
Blood urine nitrogen, μmol/L | 4.8 ± 1.7 | 4.8 ± 1.8 | 4.7 ± 1.5 | 0.816 |
Inflammatory markers | ||||
ESR, mm/h | 44.8 ± 30.6 | 35.8 ± 26.1 | 54.9 ± 32.7 | 0.053 |
CRP, g/L | 12.4 (1.6–39.5) | 17.3 ± 23.5 | 37.8 ± 41.7 | 0.069 |
C3, g/L | 1.20 ± 0.28 | 1.07 ± 0.19 | 1.34 ± 0.30 | 0.005 |
C4, g/L | 0.26 ± 0.08 | 0.25 (0.20–0.27) | 0.27 (0.22–0.34) | 0.240 |
CH50, g/L | 68.0 ± 21.5 | 61.8 ± 20.5 | 74.6 ± 21.2 | 0.100 |
IgG, g/L | 12.9 ± 3.3 | 12.4 ± 3.0 | 13.4 ± 3.6 | 0.382 |
IL-6, pg/ml | 9.3 (3.9–18.5) | 7.2 (3.7–13.6) | 14.4 (5.4–26.8) | 0.156 |
IL-8, pg/ml | 7.3 (5.0–9.2) | 7.0 (5.0–9.0) | 8.0 (5.0–22.0) | 0.493 |
SAA, mg/L | 30.4 (5.7–175.8) | 9.1 (5.1–118.0) | 104.8 (21.8–289.8) | 0.023 |
NIH score | 3.0 (2.8–4.0) | 3.0 (2.0–3.8) | 3.0 (3.0–4.0) | 0.105 |
Concomitant Immunosuppressants types, n (%) | 0.194 | |||
0 | 23 (60.5) | 12 (60.0) | 11 (61.1) | |
1 | 12 (31.6) | 5 (25.0) | 7 (38.9) | |
2 | 3 (7.9) | 3 (15.0) | 0 |