Table 1 Baseline joint assessment in ORAL Start
From: Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start
Tofacitinib 5 mg BID, N = 373 | Tofacitinib 10 mg BID, N = 397 | Methotrexate, N = 186 | |
|---|---|---|---|
Total number of joints, meana | |||
Tender joints | 25.7 | 25.1 | 25.4 |
Swollen joints | 16.3 | 15.6 | 16.8 |
mTSS and subcomponents, mean | |||
mTSS | 19.1 | 17.9 | 16.1 |
Erosion score | 9.1 | 9.1 | 8.4 |
JSN score | 10.0 | 8.8 | 7.7 |
Patients with tender/swollen joints, n (%) | |||
TM | 71 (19.0) | 100 (25.2) | 33 (17.7) |
SC | 104 (27.9) | 103 (25.9) | 43 (23.1) |
AC | 117 (31.4) | 127 (32.0) | 59 (31.7) |
Shoulder | 226 (60.6) | 235 (59.2) | 109 (58.6) |
Elbow | 208 (55.8) | 228 (57.4) | 106 (57.0) |
Wrist | 345 (92.5) | 358 (90.2) | 167 (89.8) |
Hand MCP1 | 235 (63.0) | 263 (66.2) | 119 (64.0) |
Hand MCP2 | 314 (84.2) | 339 (85.4) | 164 (88.2) |
Hand MCP3 | 317 (85.0) | 320 (80.6) | 152 (81.7) |
Hand MCP4 | 228 (61.1) | 233 (58.7) | 115 (61.8) |
Hand MCP5 | 186 (49.9) | 205 (51.6) | 106 (57.0) |
Hand IP1 | 171 (45.8) | 184 (46.3) | 75 (40.3) |
Hand PIP2 | 282 (75.6) | 290 (73.0) | 139 (74.7) |
Hand PIP3 | 280 (75.1) | 312 (78.6) | 152 (81.7) |
Hand PIP4 | 219 (58.7) | 235 (59.2) | 126 (67.7) |
Hand PIP5 | 181 (48.5) | 193 (48.6) | 97 (52.2) |
Hand DIP2 | 96 (25.7) | 94 (23.7) | 41 (22.0) |
Hand DIP3 | 97 (26.0) | 99 (24.9) | 46 (24.7) |
Hand DIP4 | 74 (19.8) | 71 (17.9) | 37 (19.9) |
Hand DIP5 | 70 (18.8) | 72 (18.1) | 33 (17.7) |
Knee | 282 (75.6) | 303 (76.3) | 127 (68.3) |
Ankle | 289 (77.5) | 300 (75.6) | 140 (75.3) |
Midtarsal | 154 (41.3) | 177 (44.6) | 86 (46.2) |
Foot MTP1 | 198 (53.1) | 194 (48.9) | 89 (47.8) |
Foot MTP2 | 206 (55.2) | 205 (51.6) | 90 (48.4) |
Foot MTP3 | 201 (53.9) | 198 (49.9) | 92 (49.5) |
Foot MTP4 | 172 (46.1) | 172 (43.3) | 84 (45.2) |
Foot MTP5 | 132 (35.4) | 140 (35.3) | 61 (32.8) |
Foot IP1 | 83 (22.3) | 94 (23.7) | 39 (21.0) |
Foot PIP2 | 70 (18.8) | 89 (22.4) | 38 (20.4) |
Foot PIP3 | 69 (18.5) | 76 (19.1) | 34 (18.3) |
Foot PIP4 | 58 (15.5) | 72 (18.1) | 40 (21.5) |
Foot PIP5 | 51 (13.7) | 56 (14.1) | 26 (14.0) |