Fig. 1

Chemokines involved in DC-T cell crosstalk. This picture summarises that chemokine ligand-receptors abundantly expressed in DCs and T cells play an important role in DC-T cell crosstalk in RA. Chemokines drive these immune cells to migrate to diseased joints and induce destructive immune responses. Black arrows indicate the promotion of proliferation and differentiation of CD4⁺T cell subtypes. Inhibition arrows in red indicate inhibition of chemokines