Variable | Total (n = 2,321) | D2T (n = 271) | Non-D2T (n = 2,050) | p-value |
---|---|---|---|---|
Demographics | ||||
 Age, years, mean (SD) | 54.6 (12.8) | 53.8 (12.4) | 54.8 (12.9) | 0.240 |
 Sex, N (%) |  |  |  | 0.148 |
  Male | 407 (17.5) | 39 (14.4) | 368 (18.0) |  |
  Female | 1,914 (82.5) | 232 (85.6) | 1,682 (82.1) |  |
 BMI, mean (SD) | 22.8 (3.5) | 22.7 (3.7) | 22.8 (3.5) | 0.632 |
 Smoking, N (%) |  |  |  | 0.973 |
  Ex-smoker | 215 (9.3) | 26 (9.6) | 189 (9.2) |  |
  Current smoker | 185 (8.0) | 21 (7.8) | 164 (8.0) |  |
  Never | 1,921 (82.8) | 224 (82.7) | 1,697 (82.8) |  |
Comorbidities | ||||
 Diabetes mellitus, N (%) | 290 (12.5) | 33 (12.2) | 257 (12.5) | 0.866 |
 Hypertension, N (%) | 703 (30.3) | 83 (30.6) | 620 (30.2) | 0.897 |
 Cardiovascular disease, N (%) | 597 (25.7) | 88 (32.5) | 509 (24.8) | 0.007 |
 Cancer, N (%) | 10 (0.4) | 2 (0.7) | 8 (0.4) | 0.329 |
Extraarticular manifestations | ||||
 Scleritis or episcleritis, N (%) | 5 (0.2) | 0 (0.0) | 5 (0.2) | - |
 Secondary Sjogren’s syndrome, N (%) | 71 (3.1) | 5 (1.9) | 66 (3.2) | 0.217 |
 Subcutaneous rheumatoid nodule, N (%) | 55 (2.4) | 12 (4.4) | 43 (2.1) | 0.018 |
 Cutaneous vasculitis, N (%) | 4 (0.2) | 1 (0.4) | 4 (0.2) | 0.393 |
 Pleuritis, N (%) | 9 (0.4) | 1 (0.4) | 8 (0.4) | - |
 Interstitial lung disease, N (%) | 140 (6.0) | 22 (8.1) | 118 (5.8) | 0.128 |
Disease status | ||||
 Disease duration, years, median [IQR] | 5.6 [1.8, 11.9] | 9.7 [5.2, 15.2] | 5 [1.6, 11.2] | < 0.001 |
 RF positivity, N (%) | 1,854 (82.9) | 201 (79.1) | 1,653 (83.4) | 0.089 |
 Anti-CCP Ab positivity, N (%) | 1,671 (85.8) | 170 (84.6) | 1,501 (85.9) | 0.606 |
 Tender joint count, median [IQR] | 7 [4, 12] | 8 [4, 14] | 7 [4, 11] | 0.073 |
 Swollen joint count, median [IQR] | 6 [3, 9] | 6 [3, 10] | 5 [2, 9] | 0.144 |
 Patient global assessment, mean (SD) | 6.83 (2.04) | 7.01 (1.99) | 6.81(2.04) | 0.130 |
 Physician global assessment, mean (SD) | 6.47 (1.82) | 6.71 (1.69) | 6.44 (1.84) | 0.024 |
 ESR, mm/hr, median [IQR] | 44 [28, 65] | 47 [29, 75] | 44 [28, 65] | 0.055 |
 CRP, mg/dL, median [IQR] | 1.25 [0.43, 2.93] | 1.72 [0.34, 3.78] | 1.21 [0.44, 2.80] | 0.033 |
 DAS28-ESR, mean (SD) | 5.52 (1.14) | 5.65 (1.15) | 5.51 (1.13) | 0.062 |
 DAS28-CRP, mean (SD) | 4.83 (1.13) | 4.98 (1.16) | 4.81 (1.12) | 0.020 |
 SDAI, mean (SD) | 28.9 (11.8) | 31.1 (12.9) | 28.6 (11.6) | 0.003 |
 CDAI, mean (SD) | 26.7 (11.0) | 28.2 (11.9) | 26.4 (10.9) | 0.02 |
 Radiographic erosions, N (%) | 889 (38.3) | 100 (36.9) | 789 (38.5) | 0.613 |
Function | ||||
 RAPID3, mean (SD) | 15.3 (5.7) | 16.8 (5.5) | 15.1 (5.6) | < 0.001 |