Arthritis Research & Therapy

Table 4 Features associated with anti-HSA-MAA⁺ antibody status in RA patients from Santiago and Barcelona

From: Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression

	IgG-anti-MAA		IgM-anti-MAA		IgA-MAA
	OR (95% CI)^a	p	OR (95% CI)	p	OR (95% CI)	p
Santiago
Sex (men)	3.3 (1.3–8.6)	0.014	1.1 (0.7–1.9)	0.6	0.9 (0.5–1.7)	0.8
Age at diagnosis	1.0 (1.0–1.0)	0.057	1.0 (1.0–1.0)	0.5	1.0 (1.0–1.0)	0.2
Disease evolution	1.0 (1.0–1.1)	0.085	1.0 (1.0–1.0)	0.4	1.0 (1.0–1.1)	7.9 × 10⁻³
Smoking (ever)	0.8 (0.2–3.0)	0.7	2.8 (1.4–5.7)	4.1 × 10⁻³	1.7 (0.6–4.5)	0.3
Anti-CCP⁺	0.7 (0.3–1.4)	0.3	3.9 (2.0–7.6)	9.0 × 10⁻⁵	2.0 (0.9–4.5)	0.095
RF⁺	0.7 (0.3–1.5)	0.3	3.5 (1.8–6.6)	1.4 × 10⁻⁴	2.6 (1.1–6.2)	0.03
SE	1.0 (0.5–2.0)	0.9	1.2 (0.7–2.0)	0.5	0.8 (0.4–1.6)	0.6
PTPN22	1.1 (0.5–2.5)	0.8	0.7 (0.4–1.4)	0.3	0.8 (0.3–1.7)	0.5
Barcelona
Sex (men)	1.7 (0.6–5.4)	0.3	-^b	-	0.7 (0.3–1.6)	0.4
Age at diagnosis	1.0 (0.9–1.0)	0.063	0.9 (0.8–1.1)	0.5	1.0 (1.0–1.0)	0.9
Disease evolution	0.9 (0.8–1.1)	0.4	0.8 (0.3–1.7)	0.5	1.1 (1.0–1.1)	0.2
Smoking (ever)	0.8 (0.2–3.0)	0.7	-	-	0.4 (0.1–1.1)	0.067
Anti-CCP⁺	0.9 (0.3–3.3)	0.9	-	-	1.1 (0.4–3.0)	0.9
RF⁺	1.0 (0.3–3.5)	0.9	-	-	0.9 (0.4–2.3)	0.9

Results of the logistic regression analysis. Sex, age at diagnosis, and disease evolution results are from univariate models. The other features were analyzed with sex, age, and disease duration as covariates
^aAbbreviations: OR odds ratio, CI confidence interval, RF rheumatoid factor, SE alleles of the shared epitope in the HLA-DRB1 gene, PTPN22 risk allele of the rs2476601 SNP in the PTPN22 gene
^bThe number of antibody positive patients was too low for analysis

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