From: Interleukin-37: associations of plasma levels and genetic variants in gout
IL-37 [pg/ml] | rs2708959 | rs2723170 | rs2708958 | rs2723169 | rs2466448 | rs3811045 | rs3811046 | rs3811047 | rs3811048 | rs2708943 | rs2723183 | rs2708944 | rs2723187 | rs2708947 | rs27231927 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median (IQR) | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | n MAF | |
European population (NCBI) | 0.050 | 0.080 | 0.081 | 0.079 | 0.079 | 0.705 | 0.705 | 0.703 | 0.704 | 0.081 | 0.082 | 0.079 | 0.081 | 0.082 | 0.082 | |
Control subjects (N = 50/50a) | 90.4 (49.9–122.5) | 8 | 8 | 8 | 8 | 8 | 67 | 67 | 67 | 67 | 8 | 8 | 8 | 10 | 7 | 7 |
0.080 | 0.080 | 0.080 | 0.080 | 0.080 | 0.670 | 0.670 | 0.670 | 0.670 | 0.080 | 0.080 | 0.080 | 0.100 | 0.070 | 0.070 | ||
Asymptomatic hyperuricemic (N = 111/146a) | 158.9 (68.8–318.1) | 8 | 8 | 8 | 8 | 8 | 109 | 109 | 109 | 109 | 10 | 10 | 9 | 8 | 8 | 8 |
0.054 | 0.054 | 0.054 | 0.054 | 0.054 | 0.736 | 0.736 | 0.736 | 0.736 | 0.068 | 0.068 | 0.061 | 0.054 | 0.054 | 0.054 | ||
Intercritical gout (N = 182/206a) | 154.0 (76.3–270.8) | 34 | 34 | 34 | 34 | 36 | 285 | 284 | 284 | 284 | 33 | 34 | 34 | 40 | 40 | 40 |
0.085 | 0.085 | 0.085 | 0.085 | 0.090 | 0.713 | 0.710 | 0.710 | 0.710 | 0.083 | 0.085 | 0.085 | 0.100 | 0.100 | 0.100 | ||
Chronic tophaceous gout (N = 20/30a) | 149.1 (83.7–188.5) | 6 | 6 | 6 | 6 | 6 | 25 | 25 | 25 | 25 | 4 | 3 | 4 | 4 | 3 | 3 |
0.139 | 0.139 | 0.139 | 0.139 | 0.139 | 0.639 | 0.639 | 0.639 | 0.639 | 0.083 | 0.056 | 0.083 | 0.083 | 0.083 | 0.083 | ||
Acute gouty flare (N = 25/20a) | 168.5 (80.3–336.2) | 5 | 5 | 5 | 5 | 5 | 34 | 34 | 34 | 34 | 2b | 2b | 2b | 3 | 3 | 3 |
0.083 | 0.083 | 0.083 | 0.083 | 0.083 | 0.567 | 0.567 | 0.567 | 0.567 | 0.034 | 0.034 | 0.034 | 0.050 | 0.050 | 0.050 |