From: Systemic sclerosis and risk of bronchiectasis: a nationwide longitudinal cohort study
Subgroups | Systemic sclerosis | N | Incident bronchiectasis (n) | Duration (PY) | IR per 1000 PY | HR (95% CI) | ||
---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | ||||||
Sex | ||||||||
 Male | No | 3685 | 67 | 20,814 | 3.22 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 737 | 27 | 3712 | 7.27 | 4.93 (3.30–7.36) | 2.28 (1.46–3.58) | 1.94 (1.23–3.06) | |
 Female | No | 20,540 | 388 | 120,049 | 3.23 | Reference | 1 (reference) | 1 (reference) |
Yes | 4108 | 232 | 22,214 | 10.44 | 2.57 (1.97–3.34) | 3.21 (2.71–3.80) | 2.74 (2.29–3.28) | |
 P for interaction |  |  |  |  |  | 0.140 | 0.163 | 0.155 |
Age, years | ||||||||
 20–39 | No | 3375 | 14 | 21,600 | 0.65 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 675 | 18 | 4131 | 4.36 | 6.73 (3.34–13.53) | 6.49 (3.22–13.04) | 5.64 (2.79–11.40) | |
 40–64 | No | 16,115 | 283 | 93,934 | 3.01 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 3223 | 171 | 17,427 | 9.81 | 3.26 (2.70–3.94) | 3.17 (2.60–3.86) | 2.68 (2.18–3.29) | |
 ≥ 65 | No | 4735 | 158 | 25,329 | 6.24 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 947 | 70 | 4366 | 16.03 | 2.58 (1.94–3.41) | 2.56 (1.93–3.40) | 2.21 (1.65–2.95) | |
 P for interaction |  |  |  |  |  | 0.036 | 0.048 | 0.048 |
Low income | ||||||||
 Others | No | 18,225 | 332 | 106,627 | 3.11 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 3655 | 194 | 19,744 | 9.83 | 3.15 (2.64–3.77) | 3.08 (2.57–3.70) | 2.63 (2.17–3.18) | |
 Q1, low | No | 6000 | 123 | 34,235 | 3.59 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 1190 | 65 | 6182 | 10.51 | 2.93 (2.17–3.95) | 3.06 (2.25–4.15) | 2.62 (1.92–3.58) | |
 P for interaction |  |  |  |  |  | 0.673 | 0.966 | 0.995 |
Comorbidities | ||||||||
 COPD | ||||||||
  No | No | 22,668 | 390 | 132,298 | 2.95 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 3886 | 177 | 21,010 | 8.42 | 2.86 (2.39–3.41) | 2.87 (2.39–3.45) | 2.67 (2.21–3.23) | |
  Yes | No | 1557 | 65 | 8564 | 7.59 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 959 | 82 | 4915 | 16.68 | 2.19 (1.58–3.04) | 2.57 (1.84–3.57) | 2.48 (1.78–3.46) | |
  P for interaction |  |  |  |  |  | 0.163 | 0.555 | 0.694 |
 Asthma | ||||||||
  No | No | 21,785 | 378 | 127,582 | 2.96 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 3944 | 189 | 21,470 | 8.80 | 2.97 (2.40–3.54) | 2.97 (2.48–3.56) | 2.65 (2.19–3.20) | |
  Yes | No | 28 | 1 | 141 | 7.06 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 24 | 4 | 108 | 36.84 | 5.22 (0.58–46.75) | 6.02 (0.67–53.99) | 6.01 (0.66–54.04) | |
  P for interaction |  |  |  |  |  | 0.633 | 0.543 | 0.459 |
 Tuberculosis | ||||||||
  No | No | 24,197 | 454 | 140,722 | 3.23 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 4821 | 255 | 25,817 | 9.88 | 3.06 (2.62–3.57) | 3.04 (2.59–3.57) | 2.61 (2.21–3.10) | |
  Yes | No | 28 | 1 | 141 | 7.06 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 24 | 4 | 108 | 36.84 | 5.22 (0.58–46.75) | 6.02 (0.67–53.99) | 6.01 (0.66–54.04) | |
  P for interaction |  |  |  |  |  | 0.633 | 0.543 | 0.459 |
 CTDs other than systemic sclerosis | ||||||||
  No | No | 24,139 | 448 | 140,414 | 3.19 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 4373 | 231 | 23,482 | 9.84 | 3.08 (2.63–3.61) | 3.04 (2.58–3.59) | 2.71 (2.28–3.21) | |
  Yes | No | 86 | 7 | 448 | 15.60 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 472 | 28 | 2444 | 11.46 | 0.73 (0.32–1.68) | 0.92 (0.40–2.11) | 0.83 (0.36–1.90) | |
  P for interaction |  |  |  |  |  | 0.001 | 0.005 | 0.006 |