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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway

Fig. 1

The expression of Rspo2 in RA mouse model and RA patients. A Representative images and statistical analysis of HE staining and Rspo2 immunohistochemical staining in control and RA human synovial tissue (n = 8 per group). Scale bars: 50 μm. B Western blot of Rspo2 expression in human synovial tissue. C Representative images and statistical analysis of Safranin O/Fast Green staining and Rspo2 immunohistochemical staining in control and RA human cartilage tissue (n = 8 per group). Scale bars: 100 μm. D Representative images and statistical analysis of HE staining and Rspo2 immunostaining in the synovium from a RA mouse model and control group (n = 6 per group). Scale bars: 50 μm. E Representative images and statistical analysis of Safranin O/Fast Green staining and Rspo2 immunostaining in knee cartilage from a RA mouse model and control group (n = 6 per group). Scale bars: 50 μm. F Rspo2 concentrations assessed by an ELISA in the serum of sham and RA mice at 4 and 8 weeks after AIA modeling (n = 6 per group). Student’s t-test. *P < 0.05, **P < 0.01. Data are shown as mean ± SEM

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Arthritis Research & Therapy

ISSN: 1478-6362

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