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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway

Fig. 3

Rspo2 causes strikingly progressive synovial hyperplasia, production of inflammatory cytokines, and articular cartilage loss in RA mice. A HE staining of synovial tissues from sham and RA mice administrated with vehicle, rmRspo2, Rspo2-NAb, and rmDKK1 for 4 and 8 weeks. Scale bars: 50 μm. B Safranin O/Fast Green staining of knee cartilage from sham and RA mice treated with vehicle, rmRspo2, Rspo2-NAb, and rmDKK1 for 4 and 8 weeks. Scale bars: 50 μm. C Synovitis score for the joints described in A (n = 6 per group). D Osteoarthritis Research Society International grades for the joints described in B (n = 6 per group). E–H TNF-α and IL-1β concentrations assessed by an ELISA in the serum of sham and RA mice treated with vehicle, rmRspo2, Rspo2-NAb, and rmDKK1 for 4 and 8 weeks (n = 6 per group). One-way analysis of variance (ANOVA) and Tukey’s multiple comparison test. *P < 0.05, **P < 0.01. Data are shown as mean ± SEM

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Arthritis Research & Therapy

ISSN: 1478-6362

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