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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway

Fig. 5

Recombinant Rspo2 promotes proliferation, migration, invasion, and the expression of inflammatory cytokines in FLS. A Representative images and quantitative analysis of immunofluorescence staining for BrdU (green) in rhRspo2-treated FLS with or without Rspo2-NAb or rhDKK1 (n = 3 per group). Scale bar: 25 μm. B, C Representative images and quantitative analysis of Transwell assays (B) and wound-healing assays (C) in rhRspo2-treated FLS with or without Rspo2-NAb or rhDKK1 (n = 3 per group). Scale bar: 100 μm. D–F Relative mRNA expression level of TNF-α (D), IL-1β (E), and IL-6 (F) in rhRspo2-treated FLS with or without Rspo2-NAb or rhDKK1 (n = 3 per group). One-way analysis of variance (ANOVA) and Tukey’s multiple comparison test. *P < 0.05, **P < 0.01. Data are shown as mean ± SEM

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Arthritis Research & Therapy

ISSN: 1478-6362

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