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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway

Fig. 6

Rspo2 disrupt chondrocyte homeostasis in RA. A Immunofluorescence staining and statistical analysis of Col2a1 in the knee cartilage from sham and RA mice administered with a vehicle, rmRspo2, Rspo2-NAb, or rmDKK1 (n = 6 per group). Scale bar: 25 μm. B, C Representative immunohistochemical images and statistical analysis of ACAN and MMP13 in the knee cartilage from sham and RA mice administrated with a vehicle, rmRspo2, Rspo2-NAb, or rmDKK1 (n = 6 per group). Scale bar: 25 μm. D, E Western blot (D) and quantitative PCR analysis (E) of ANAN, Col2a1, Sox9, and MMP13 in rmRspo2-treated chondrocytes with or without Rspo2-NAb or rmDKK1 (n = 3 per group). One-way analysis of variance (ANOVA) and Tukey’s multiple comparison test. *P < 0.05, **P < 0.01. Data are shown as mean ± SEM

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Arthritis Research & Therapy

ISSN: 1478-6362

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