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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis

Fig. 2

CD19+ B cell proliferation following stimulation for 6 days. Cell proliferation was assessed by a CellTrace violet (CTV) staining in CD19+ B cells of healthy controls (HD) compared to RA/SLE patients after stimulation for 6 days with 1 µg/ml ODN2006 (CpG) or with T cell-dependent stimulation with CD3 (clone 1XE) and CD28 (clone 15E8) soluble antibodies. RA patients were all treated with methotrexate, while one patient also received prednisolone 5 mg/day (+). Two SLE patients were de novo (no mediation; 1+5), while most SLE patients received hydroxychloroquine (HCQ; 2,3,4) or a combination of HCQ with either azathioprine (6) or prednisone 15 mg/day (8), one SLE patient was treated with mycophenolate mofetil (7). Filled symbols represent active disease, open symbols remission. Two-way Anova test was used for statistical analyses; ns = not significant. Data are expressed as mean ± SD.

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Arthritis Research & Therapy

ISSN: 1478-6362

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