From: Risk prediction model for mortality in microscopic polyangiitis: multicentre REVEAL cohort study
Characteristics | Death (N = 60) | Survive (N= 134) | P value |
---|---|---|---|
Age, year | 76.2 (71.5–83.1) | 72.3 (65.9–77.2) | < 0.0001 |
Female, n (%) | 29(48.3) | 78 (58.2) | 0.215 |
Observation period from baseline, weeks | 128.5 (35.3–248) | 229 (112–392) | < 0.0001 |
Smoking history, n (%) | 31 (56.4)a | 63 (51.6)b | 0.627 |
Smoking index | 950 (800–1200) | 600 (300–920) | 0.002 |
Laboratory findings | |||
WBC, /mm3 | 12005 (8063–16,648) | 10110(7300–13,815) | 0.086 |
Hb, g/dL | 9.7 (8.2–11.9) | 10.3 (9.0–11.9)c | 0.325 |
Alb, g/dL | 2.5 (2.1–2.9) | 2.8 (2.3–3.3)c | 0.025 |
Cre, mg/dL | 1.34 (0.8–2.2) | 1.0 (0.67–2.04) | 0.056 |
CRP, mg/dL | 9.3 (4.19–13.29) | 6.8 (1.48–12.0) | 0.031 |
Positive, anti-MPO-ANCA, n (%) | 59(98.3) | 133 (99.3) | 0.524 |
Positive, anti-PR3-ANCA, n (%) | 3 (5.0) | 7 (5.2) | 1 |
MPO-ANCA titre, U/mL | 122.5 (57.7–240.8) | 119 (46.1–251.0) | 0.95 |
BVAS at onset | 17.5 (11.3–22.8) | 12 (7.0–18.0) | 0.005 |
Five factor score 2009 | |||
≤1 | 5 (8.3) | 34 (25.4) | 0.019 |
2 | 39 (65.0) | 68 (50.8) | |
≥3 | 16 (26.7) | 32 (23.9) | |
EUVAS categorization system | |||
Localized | 1 (1.7) | 6 (4.5) | 0.037 |
Early systemic | 12 (20.0) | 34 (25.4) | |
Systemic | 30 (50.0) | 78 (58.2) | |
Severe | 17 (28.3) | 16 (11.9) | |
Initial treatment | |||
PDN, mg/kg/day | 1.0 (0.6–1.0) | 1.0 (0.6–1.0)c | 0.829 |
MPDN pulse therapy, n (%) | 20 (35.1) | 40 (32.0) | 0.735 |
Immunosuppressants | |||
IVCY, n (%) | 21 (37.5) | 50 (42.7) | 0.621 |
Total IVCY dose (g) | 0.13 (0–1.0) | 0.0 (0–2.0) | 0.589 |
RTX, n (%) | 4 (6.7) | 12 (9.0) | 0.78 |
IVIG, n (%) | 1 (1.7) | 7 (5.2) | 0.439 |
AZA, n (%) | 33 (55.0) | 70 (52.2) | 0.757 |
MMF, n (%) | 1 (1.7) | 2 (1.5) | 1 |
Plasma exchange, n (%) | 9 (15.0) | 6 (4.5) | 0.018 |
Haemodialysis, n (%) | 7 (11.7) | 10 (7.5) | 0.411 |
Relapse, n (%) | 22 (36.7) | 50 (37.3) | 1 |
Relapse, time | 0 (0–1) | 0 (0–1) | 0.83 |
Cause of death, n (%) | MPA-related vasculitis 11 (18.3), infections 30 (50.0), others 19 (31.7) | - | - |