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  1. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a large production of autoantibodies and deficient clearance of cellular waste. The disease typically oscillates between episodes of...

    Authors: Jesper Karlsson, Jonas Wetterö, Maria Weiner, Johan Rönnelid, Rafael Fernandez-Botran and Christopher Sjöwall
    Citation: Arthritis Research & Therapy 2022 24:139
  2. Rheumatic heart disease (RHD) is a critical public health issue worldwide, and its epidemiological patterns have changed over the decades. This article aimed to estimate the global trends of RHD, and attributa...

    Authors: Zejin Ou, Danfeng Yu, Yuanhao Liang, Jinhua Wu, Huan He, Yongzhi Li, Wenqiao He, Yuhan Gao, Fei Wu and Qing Chen
    Citation: Arthritis Research & Therapy 2022 24:138
  3. Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic biomarkers or disease-modifying drugs, though promising candidates such as dexamethasone (Dex) exist. Many challenges in studyin...

    Authors: Rebecca Mae Black, Lisa L. Flaman, Karin Lindblom, Susan Chubinskaya, Alan J. Grodzinsky and Patrik Önnerfjord
    Citation: Arthritis Research & Therapy 2022 24:137
  4. To evaluate the efficacy and safety of HLX01, a rituximab biosimilar, as combination therapy with methotrexate in Chinese patients with active rheumatoid arthritis who had inadequate responses to methotrexate.

    Authors: Xiaofeng Zeng, Ju Liu, Xiumei Liu, Lijun Wu, Yi Liu, Xiangping Liao, Huaxiang Liu, Jiankang Hu, Xin Lu, Linjie Chen, Jian Xu, Zhenyu Jiang, Fu-ai Lu, Huaxiang Wu, Ying Li, Qingyu Wang…
    Citation: Arthritis Research & Therapy 2022 24:136
  5. Infection is one of the primary concerns during treatment for rheumatoid arthritis (RA) in elderly patients. However, infection risk of patients with RA receiving targeted therapy (TT) including biological dis...

    Authors: Ryoko Sakai, Eiichi Tanaka, Masako Majima and Masayoshi Harigai
    Citation: Arthritis Research & Therapy 2022 24:135
  6. Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown...

    Authors: Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2022 24:134
  7. Subcutaneous tocilizumab (TCZ SC) is approved globally for giant cell arteritis (GCA). This phase Ib study investigated the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of intravenous (...

    Authors: Christophe Schmitt, Laura Brockwell, Mylène Giraudon, Mauro Zucchetto, Lisa Christ, Bettina Bannert, Thomas Daikeler and Peter M. Villiger
    Citation: Arthritis Research & Therapy 2022 24:133
  8. Rituximab is used for the treatment of active rheumatoid arthritis. In the present study, we examined the long-term flare risk and safety of reduced doses of rituximab.

    Authors: Antonios Bertsias, Nestor Avgoustidis, Ioannis Papalopoulos, Argyro Repa, Nikolaos Kougkas, Eleni Kalogiannaki, Georgios Bertsias, Irini Flouri and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2022 24:132
  9. To analyse the subsequent clinical course of patients with rheumatoid arthritis (RA) who either continued or discontinued biologic agents after hospitalization for infections.

    Authors: Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura…
    Citation: Arthritis Research & Therapy 2022 24:131
  10. We report results from a phase II randomised placebo-controlled trial assessing zibotentan, a highly selective endothelin receptor antagonist (ERA), in chronic kidney disease (CKD) secondary to systemic sclero...

    Authors: Edward P. Stern, Lauren V. Host, Ivy Wanjiku, K. Jane Escott, Peter S. Gilmour, Rachel Ochiel, Robert Unwin, Aine Burns, Voon H. Ong, Helen Cadiou, Aidan G. O’Keeffe and Christopher P. Denton
    Citation: Arthritis Research & Therapy 2022 24:130
  11. Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.

    Authors: Yujie Ning, Minhan Hu, Yi Gong, Ruitian Huang, Ke Xu, Sijie Chen, Feiyu Zhang, Yanli Liu, Feihong Chen, Yanhai Chang, Guanghui Zhao, Cheng Li, Rong Zhou, Mikko J. Lammi, Xiong Guo and Xi Wang
    Citation: Arthritis Research & Therapy 2022 24:129
  12. Knee joint injuries, common in athletes, have a high risk of developing post-traumatic osteoarthritis (PTOA). Ligaments, matrix-rich connective tissues, play important mechanical functions stabilising the knee...

    Authors: Lorenzo Ramos-Mucci, Ahmed Elsheikh, Craig Keenan, Ashkan Eliasy, Kristiaan D’Aout, George Bou-Gharios, Eithne Comerford and Blandine Poulet
    Citation: Arthritis Research & Therapy 2022 24:128
  13. Although the survival rates of patients with relapsing polychondritis (RP) have increased remarkably, the high recurrence rate remains a significant concern for physicians and patients. This retrospective stud...

    Authors: Tsuneyasu Yoshida, Hajime Yoshifuji, Mirei Shirakashi, Akiyoshi Nakakura, Kosaku Murakami, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Koichiro Ohmura and Akio Morinobu
    Citation: Arthritis Research & Therapy 2022 24:127
  14. Insulin resistance and beta-cell dysfunction are manifestations of rheumatoid arthritis (RA). Apolipoprotein C-III (ApoC3) has been associated with such insulin resistance and beta-cell dysfunction in the gene...

    Authors: Candelaria Martín-González, Tomás Martín-Folgueras, Juan Carlos Quevedo-Abeledo, Antonia de Vera-González, Alejandra González-Delgado, Laura de Armas-Rillo, Miguel Á. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2022 24:126
  15. Rheumatoid arthritis (RA) requires early diagnosis and tight surveillance of disease activity. Remote self-collection of blood for the analysis of inflammation markers and autoantibodies could improve the moni...

    Authors: Johannes Knitza, Koray Tascilar, Nicolas Vuillerme, Ekaterina Eimer, Paul Matusewicz, Giulia Corte, Louis Schuster, Timothée Aubourg, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch, Arnd Kleyer, Sebastian Boeltz, Axel J. Hueber, Gerhard Krönke, Georg Schett…
    Citation: Arthritis Research & Therapy 2022 24:125
  16. Foot involvement is a significant concern in psoriatic arthritis (PsA) as it can lead to severe levels of foot pain and disability and reduced mobility and quality of life. Previous studies have shown moderate...

    Authors: Roua Walha, Pierre Dagenais, Nathaly Gaudreault, Gabriel Beaudoin-Côté and Patrick Boissy
    Citation: Arthritis Research & Therapy 2022 24:124
  17. Authors: Johannes Knitza and Axel J. Hueber
    Citation: Arthritis Research & Therapy 2022 24:123

    The original article was published in Arthritis Research & Therapy 2022 24:82

    The original article was published in Arthritis Research & Therapy 2021 23:233

  18. With great interest, we have read the recent article “The risk of malignancy in patients with IgG4-related disease: a systematic review and meta-analysis” by Yu et al. While we have a great appreciation for th...

    Authors: Hann-Ziong Yueh, James Cheng-Chung Wei and Liyun Zhang
    Citation: Arthritis Research & Therapy 2022 24:122

    The original article was published in Arthritis Research & Therapy 2022 24:14

  19. Primary Sjogren’s syndrome (pSS) is a heterogeneous chronic autoimmune disorder characterized by lymphocyte infiltration of the exocrine glands and the involvement and dysfunction of multiple organs and tissue...

    Authors: Lei Shi, Jia Wang, Hong-Xia Guo, Xiao-Lei Han, Yu-Ping Tang and Guang-Ying Liu
    Citation: Arthritis Research & Therapy 2022 24:121
  20. Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection. To improve therapeutic approaches, identification of specific molecu...

    Authors: Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2022 24:120
  21. Mechanical stress plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). The mechanosensitive Piezo1 ion channel can sense the changes in mechanical stress and convert the mechani...

    Authors: Sheng Shi, Xing-Jian Kang, Zhi Zhou, Zhi-Min He, Shuang Zheng and Shi-Sheng He
    Citation: Arthritis Research & Therapy 2022 24:119
  22. Fluorescence optical imaging (FOI) enables visualisation of inflammation in both hands in rheumatoid arthritis (RA).

    Authors: S. Hertrampf, J. Klotsche, Q. Schefer, A. M. Glimm, G. R. Burmester, P. Hoff, G. Schmittat, T. Häupl, S. Hermann, M. Backhaus and Sarah Ohrndorf
    Citation: Arthritis Research & Therapy 2022 24:117
  23. The aim of this national population-based, retrospective database study is to compare the comorbidity profiles of systemic lupus erythematosus (SLE) patients and general population controls matched for age, ge...

    Authors: Fruzsina Kósa, Péter Kunovszki, Judit Gimesi-Országh, Melinda Kedves, Melinda Szabó, Chetan S. Karyekar and György Nagy
    Citation: Arthritis Research & Therapy 2022 24:116
  24. This study aimed to search for blood biomarkers among the profiles of patients with RA-ILD by using machine learning classifiers and probe correlations between the markers and the characteristics of RA-ILD.

    Authors: Yan Qin, Yanlin Wang, Fanxing Meng, Min Feng, Xiangcong Zhao, Chong Gao and Jing Luo
    Citation: Arthritis Research & Therapy 2022 24:115
  25. Authors: Lingyi Li, Shelby Marozoff, Na Lu, Hui Xie, Jacek A. Kopec, Jolanda Cibere, John M. Esdaile and J. Antonio Avina-Zubieta
    Citation: Arthritis Research & Therapy 2022 24:114

    The original article was published in Arthritis Research & Therapy 2022 24:85

  26. The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been reported to be involved in the pathological process of osteoarthritis (OA) inflammation. ...

    Authors: Ganggang Kong, Jinyang Wang, Rong Li, Zhiping Huang and Le Wang
    Citation: Arthritis Research & Therapy 2022 24:113
  27. Patients with systemic lupus erythematosus (SLE) have substantial unmet medical need. Baricitinib is a Janus kinase (JAK)1 and 2 inhibitor that was shown to have therapeutic benefit in patients with SLE in a p...

    Authors: Thomas Dörner, Ronald F. van Vollenhoven, Andrea Doria, Bochao Jia, Jorge A. Ross Terres, Maria E. Silk, Stephanie de Bono, Peter Fischer and Daniel J. Wallace
    Citation: Arthritis Research & Therapy 2022 24:112
  28. To investigate the imaging characteristics and clinically assess heel enthesitis in spondyloarthritis (SpA) by applying in a post hoc analysis the Heel Enthesitis Magnetic Resonance Imaging Scoring system (HEM...

    Authors: X. Baraliakos, P. Sewerin, E. de Miguel, E. Pournara, C. Kleinmond, A. Shekhawat, C. Jentzsch, A. Wiedon and F. Behrens
    Citation: Arthritis Research & Therapy 2022 24:111
  29. B cells have been highlighted in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the identification of activated B cells in granulomatous lesions and the efficacy ...

    Authors: Chen Wang, Zhi-Ying Li, Yan Gong, Ran You, Ming-Hui, Zhao and Min Chen
    Citation: Arthritis Research & Therapy 2022 24:109
  30. Systemic sclerosis (SSc) is a disease of connective tissue with high rate of morbidity and mortality highlighted by extreme fibrosis affecting various organs such as the dermis, lungs, and heart. Until now, t...

    Authors: Mohsen Rokni, Mina Sadeghi Shaker, Hoda Kavosi, Shahrzad Shokoofi, Mahdi Mahmoudi and Elham Farhadi
    Citation: Arthritis Research & Therapy 2022 24:108
  31. Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity and mortality. That is why ILD screening at a v...

    Authors: Tobias Hoffmann, Peter Oelzner, Marcus Franz, Ulf Teichgräber, Diane Renz, Martin Förster, Joachim Böttcher, Claus Kroegel, P. Christian Schulze, Gunter Wolf and Alexander Pfeil
    Citation: Arthritis Research & Therapy 2022 24:107
  32. In IgG4-related disease, the relationship between pathological findings and relapse has not been well established. This study aimed to identify the clinical and pathological predictors of disease relapse in Ig...

    Authors: Ji Zongfei, Chen Lingli, Sun Ying, Ma Lingying, Zhang Lijuan, Liu Dongmei, Dai Xiaomin, Hou Yingyong, Chen Huiyong, Ma Lili and Jiang Lindi
    Citation: Arthritis Research & Therapy 2022 24:106
  33. Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and contributes to heavy socioeconomic burden. Current pharmacological and conventional non-pharmacological therapies aim at ...

    Authors: Penghui Zhang, Kaihu Li, Amir Kamali, Reihane Ziadlou, Paras Ahmad, Xinluan Wang, R. Geoff Richards, Mauro Alini, Valentina Basoli, Zhen Li and Sibylle Grad
    Citation: Arthritis Research & Therapy 2022 24:105
  34. Systemic lupus erythematosus (SLE) has been associated with atherosclerotic cardiovascular disease (CV) and an altered lipid profile. High levels of apolipoprotein C-III (ApoC3) are associated with elevated tr...

    Authors: Candelaria Martín-González, Carmen Ferrer-Moure, Juan Carlos Quevedo-Abeledo, Antonia de Vera-González, Alejandra González-Delgado, Julio Sánchez-Martín, Miguel Á. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2022 24:104
  35. To describe the epidemiology, determinants and survival impact of gastric antral vascular ectasia (GAVE) in systemic sclerosis (SSc).

    Authors: Kathleen Morrisroe, Dylan Hansen, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Catherine Hill, Janet Roddy, Jennifer Walker, Susanna Proudman and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2022 24:103
  36. Aortic valve involvement is not uncommon in patients with Takayasu arteritis (TAK) and leading to poor prognosis. The aim of our study was to explore the risk factors of aortic valve involvement and to evaluat...

    Authors: Xuemei Shi, Juan Du, Taotao Li, Na Gao, Wei Fang, Suwei Chen, Zhiyu Qiao, Chengnan Li, Junming Zhu and Lili Pan
    Citation: Arthritis Research & Therapy 2022 24:102
  37. Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune disease...

    Authors: Magdalena Keindl, Richard Davies, Brith Bergum, Johan G. Brun, Daniel Hammenfors, Roland Jonsson, Valeriya Lyssenko and Silke Appel
    Citation: Arthritis Research & Therapy 2022 24:101
  38. Polyunsaturated fatty acid (PUFA) supplementation has been reported to improve disease activity in inflammatory rheumatic diseases (IRDs). However, data are often conflicting and studies insufficiently large t...

    Authors: Johanna Sigaux, Sylvain Mathieu, Yann Nguyen, Pauline Sanchez, Jean-Guillaume Letarouilly, Martin Soubrier, Sébastien Czernichow, René-Marc Flipo, Jérémie Sellam and Claire Daïen
    Citation: Arthritis Research & Therapy 2022 24:100
  39. Modulators of triglyceride metabolism include lipoprotein lipase (LPL), angiopoietin-like protein 4 (ANGPTL4), and apolipoprotein C-3 (ApoC3). There is evidence on the influence of this triangle of molecules o...

    Authors: Laura de Armas-Rillo, Juan Carlos Quevedo-Abeledo, Vanesa Hernández-Hernández, Antonia de Vera-González, Alejandra González-Delgado, José A. García-Dopico, Miguel Á. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2022 24:99
  40. Behçet’s syndrome (BS) is a rare variant vasculitis which can involve the eyes and gastrointestinal systems. However, ocular involvement rarely overlaps with intestinal lesions. This study aimed to compare the...

    Authors: Cheng-cheng Hou, Dan Luo, Hua-fang Bao, Jing-fen Ye, Hai-fen Ma, Yan Shen, Jun Zou and Jian-long Guan
    Citation: Arthritis Research & Therapy 2022 24:98
  41. This study explored the systemic vascular effects of local cryotherapy with a focus on endothelial changes and arterial inflammation in the model of rat adjuvant-induced arthritis (AIA).

    Authors: C. Peyronnel, P. Totoson, V. Petitcolin, F. Bonnefoy, X. Guillot, P. Saas, F. Verhoeven, H. Martin and C. Demougeot
    Citation: Arthritis Research & Therapy 2022 24:97
  42. The effects of bone marrow mesenchymal stem cells (BMSCs) during the treatment of cartilage damage have been proven to be attributed to paracrine mechanisms, particularly the effect of exosomes. Exosomes from ...

    Authors: Li-tao Shao, Liang Luo, Jie-hong Qiu and David Y. B. Deng
    Citation: Arthritis Research & Therapy 2022 24:96
  43. Autologous hematopoietic stem cell transplantation (AHSCT) treats patients with severe and progressive systemic sclerosis (SSc). However, basic mechanisms associated with the therapeutic efficacy of the proced...

    Authors: Djúlio C. Zanin-Silva, Maynara Santana-Gonçalves, Marianna Y. Kawashima-Vasconcelos, João R. Lima-Júnior, Juliana B. E. Dias, Daniela A. Moraes, Dimas T. Covas, Kelen C. R. Malmegrim, Leandra Ramalho and Maria Carolina Oliveira
    Citation: Arthritis Research & Therapy 2022 24:95
  44. Systemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin and internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays a central role i...

    Authors: Akira Utsunomiya, Takenao Chino, Hiroshi Kasamatsu, Takumi Hasegawa, Natsuko Utsunomiya, Vu Huy Luong, Takashi Matsushita, Yoko Sasaki, Dai Ogura, Shin-ichiro Niwa, Noritaka Oyama and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2022 24:94
  45. Osteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of the synovial membrane. Fucosylation is an important feature of protei...

    Authors: Hanjie Yu, Mingxiu Li, Xiaodong Wen, Jie Yang, Xiaojun Liang, Xia Li, Xiaojuan Bao, Jian Shu, Xiameng Ren, Wentian Chen, Zheng Li and Yi Li
    Citation: Arthritis Research & Therapy 2022 24:93
  46. High-dose glucocorticoids (GC) are first-line treatment for adult-onset Still’s disease (AOSD); however, some of the patients remain refractory to initial GC therapy, or rapidly relapse. The aim of this study ...

    Authors: Fumiaki Kondo, Takahiko Sugihara, Natsuka Umezawa, Hisanori Hasegawa, Tadashi Hosoya, Naoki Kimura, Masaaki Mori and Shinsuke Yasuda
    Citation: Arthritis Research & Therapy 2022 24:92
  47. Pregnancy in systemic sclerosis (SSc) patients is no more an infrequent event as it used to be, but literature data on pregnancy outcomes in women with SSc are scarce. The rate of preterm deliveries and intrau...

    Authors: Giuseppe Barilaro, Aleida Castellanos, Inês Gomez-Ferreira, Gema Maria Lledó, Carlo Della Rocca, Lorena Fernandez-Blanco, Ricard Cervera, Núria Baños, Francesc Figueras and Gerard Espinosa
    Citation: Arthritis Research & Therapy 2022 24:91
  48. Current understanding of IL-23 biology, with its link to other pro-inflammatory cytokines, for example, IL-17 and granulocyte macrophage-colony stimulating factor (GM-CSF), is primarily focused on T lymphocyte...

    Authors: Kevin M.-C. Lee, Jonathan P. Sherlock and John A. Hamilton
    Citation: Arthritis Research & Therapy 2022 24:89

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