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  1. Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-morta...

    Authors: Seema Sharma, Darren Plant, John Bowes, Alex Macgregor, Suzanne Verstappen, Anne Barton and Sebastien Viatte
    Citation: Arthritis Research & Therapy 2022 24:90
  2. To explore the frequency and predictors of flares over 2 years during a treat-to-target strategy with urate-lowering therapy (ULT) in patients with gout.

    Authors: Till Uhlig, Lars F. Karoliussen, Joe Sexton, Tore K. Kvien, Espen A. Haavardsholm, Fernando Perez-Ruiz and Hilde Berner Hammer
    Citation: Arthritis Research & Therapy 2022 24:88
  3. In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not c...

    Authors: Fatima Alduraibi, Huma Fatima, Jennie A. Hamilton, W. Winn. Chatham, Hui-Chen Hsu and John D. Mountz
    Citation: Arthritis Research & Therapy 2022 24:87
  4. We explored whether serum cytokines could be used as biomarkers for optimal use of tumor necrosis factor inhibitors (TNF-i) and interleukin (IL)-17 inhibitors (IL-17-i) in patients with psoriatic arthritis (PsA).

    Authors: Ippei Miyagawa, Shingo Nakayamada, Masanobu Ueno, Yusuke Miyazaki, Shigeru Iwata, Satoshi Kubo, Koshiro Sonomoto, Junpei Anan, Naoaki Ohkubo, Yoshino Inoue and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:86
  5. The use of tramadol among osteoarthritis (OA) patients has been increasing rapidly around the world, but population-based studies on its safety profile among OA patients are scarce. We sought to determine if t...

    Authors: Lingyi Li, Shelby Marozoff, Na Lu, Hui Xie, Jacek A. Kopec, Jolanda Cibere, John M. Esdaile and J. Antonio Aviña-Zubieta
    Citation: Arthritis Research & Therapy 2022 24:85

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:114

  6. Skeletal muscle can be directly affected by systemic sclerosis (SSc); however, a significant burden of SSc-associated myopathy is undetected because clinical parameters such as weakness and creatine kinase (CK...

    Authors: Laura Ross, Anniina Lindqvist, Benedict Costello, Dylan Hansen, Zoe Brown, Jessica A. Day, Wendy Stevens, Andrew Burns, Warren Perera, Marcus Pianta, André La Gerche and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2022 24:84
  7. Fatigue, a common symptom of rheumatoid arthritis (RA), is detrimental to health-related quality of life (HRQoL). We evaluated the impact of tofacitinib on fatigue, sleep, and HRQoL and explored associations b...

    Authors: Susan J. Bartlett, Clifton O. Bingham, Ronald van Vollenhoven, Christopher Murray, David Gruben, David A. Gold and David Cella
    Citation: Arthritis Research & Therapy 2022 24:83
  8. Primary systemic vasculitis (PSV) is a heterogeneous group of autoimmune conditions. There is an unmet need for alternative therapies that lead to sustained remission in patients with refractory disease. Alemt...

    Authors: Seerapani Gopaluni, Rona Smith, Donna Goymer, Hugh Cahill, Elizabeth Broadhurst, Elizabeth Wallin, Mark McClure, Afzal Chaudhry and David Jayne
    Citation: Arthritis Research & Therapy 2022 24:81
  9. IgG4-related ophthalmic disease (IgG4ROD) is a phenotype of IgG4-related disease (IgG4RD) with ophthalmic involvement. The pathological IgG4+ plasmacyte count has only been used for diagnosis. We aimed to expl...

    Authors: Yiqun Yuan, Fengxi Meng, Hui Ren, Han Yue, Kang Xue and Rui Zhang
    Citation: Arthritis Research & Therapy 2022 24:80
  10. Rheumatoid arthritis (RA) often causes cervical spine lesions as the disease condition progresses, which induce occipital neuralgia or cervical myelopathy requiring surgical interventions. Meanwhile, patients ...

    Authors: Koji Sakuraba, Yuki Omori, Kazuhiro Kai, Kazumasa Terada, Nobuo Kobara, Satoshi Kamura, Kenjiro Fujimura, Hirofumi Bekki, Masanari Ohta, Hisa-aki Miyahara and Jun-ichi Fukushi
    Citation: Arthritis Research & Therapy 2022 24:79
  11. A recent phase 3 study demonstrated that treatment with tanezumab, a nerve growth factor inhibitor, or nonsteroidal anti-inflammatory drugs (NSAIDs) improves pain and physical function in participants with mod...

    Authors: Tuhina Neogi, David J. Hunter, Melvin Churchill, Ivan Shirinsky, Alexander White, Ali Guermazi, Masanari Omata, Robert J. Fountaine, Glenn Pixton, Lars Viktrup, Mark T. Brown, Christine R. West and Kenneth M. Verburg
    Citation: Arthritis Research & Therapy 2022 24:78
  12. There is an urgent need to identify novel biomarkers of LN to reflect renal histological changes. This study aims to investigate urinary G3BP levels in LN patients and their association with renal disease acti...

    Authors: Huihua Ding, Yiwei Shen, Cheng Lin, Ling Qin, Shijun He, Min Dai, Shinji L. Okitsu, Julie A. DeMartino, Qiang Guo and Nan Shen
    Citation: Arthritis Research & Therapy 2022 24:77
  13. Exercise has an anti-inflammatory effect and reduces fat mass. Leptin has been known to be proinflammatory adipokines mainly produced by adipocytes. However, few studies have investigated the association betwe...

    Authors: Young Bin Joo, Kyoung Bo Lee, Bomi Sul, Hye-Soon Lee, Seong Hoon Lim and Yune-Jung Park
    Citation: Arthritis Research & Therapy 2022 24:76
  14. Early diagnostics of axial spondyloarthritis (axSpA) remains a challenge. Traditional imaging one-plane sacroiliac joint (SIJ) MRI assessment is used. By introducing a two-plane assessment system, the objectiv...

    Authors: Rosa Marie Kiil, Clara E. Mistegaard, Anne Gitte Loft, Anna Zejden, Oliver Hendricks and Anne Grethe Jurik
    Citation: Arthritis Research & Therapy 2022 24:75
  15. Biological disease-modifying antirheumatic drugs (bDMARDs) are effective in the treatment of rheumatoid arthritis. However, as bDMARDs may also lead to adverse events and are expensive, tapering them is of gre...

    Authors: Matthijs S. van der Leeuw, Marianne A. Messelink, Janneke Tekstra, Ojay Medina, Jaap M. van Laar, Saskia Haitjema, Floris Lafeber, Josien J. Veris-van Dieren, Marlies C. van der Goes, Alfons A. den Broeder and Paco M. J. Welsing
    Citation: Arthritis Research & Therapy 2022 24:74
  16. Intravenous (IV) golimumab, a TNFi, is approved for treating rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). We analyzed pooled safety results from three phase 3 IV golim...

    Authors: M. Elaine Husni, Atul Deodhar, Sergio Schwartzman, Soumya D. Chakravarty, Elizabeth C. Hsia, Jocelyn H. Leu, Yiying Zhou, Kim H. Lo and Arthur Kavanaugh
    Citation: Arthritis Research & Therapy 2022 24:73
  17. To validate the ability of PROS (vitamin K-dependent protein S) and CO7 (complement component C7) to predict response to the methotrexate (MTX)/etanercept (ETA) combination in rheumatoid arthritis (RA) patient...

    Authors: Olivier Vittecoq, Clément Guillou, Julie Hardouin, Baptiste Gerard, Francis Berenbaum, Arnaud Constantin, Nathalie Rincheval, Bernard Combe, Thierry Lequerre and Pascal Cosette
    Citation: Arthritis Research & Therapy 2022 24:72
  18. To eliminate the disparity and maldistribution of physicians and medical specialty services, the development of diagnostic support for rare diseases using artificial intelligence is being promoted. Immunoglobu...

    Authors: Motohisa Yamamoto, Masanori Nojima, Ryuta Kamekura, Akiko Kuribara-Souta, Masaaki Uehara, Hiroki Yamazaki, Noritada Yoshikawa, Satsuki Aochi, Ichiro Mizushima, Takayuki Watanabe, Aya Nishiwaki, Toshihiko Komai, Hirofumi Shoda, Koji Kitagori, Hajime Yoshifuji, Hideaki Hamano…
    Citation: Arthritis Research & Therapy 2022 24:71
  19. The unmet need in systemic lupus erythematosus (SLE) with the current standard of care is widely recognised, but few studies have quantified this. The recent definition of treat-to-target endpoints and other t...

    Authors: Rangi Kandane-Rathnayake, Worawit Louthrenoo, Alberta Hoi, Shue-Fen Luo, Yeong-Jian J. Wu, Yi-Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Sandra V. Navarra, Leonid Zamora, Sargunan Sockalingam, Yuan An, Zhanguo Li, Yasuhiro Katsumata, Masayoshi Harigai…
    Citation: Arthritis Research & Therapy 2022 24:70
  20. Authors: Spandana Maddukuri, Jay Patel, De Anna Diaz, Kristen L. Chen, Maria Wysocka, Christina Bax, Yubin Li, Adarsh Ravishankar, Madison Grinnell, Majid Zeidi, Nithin Reddy, Josef Symon S. Concha, Muhammad M. Bashir, Joyce Okawa, Barbara White and Victoria P. Werth
    Citation: Arthritis Research & Therapy 2022 24:69

    The original article was published in Arthritis Research & Therapy 2022 24:12

  21. Histopathology is widely used to analyze clinical biopsy specimens and tissues from pre-clinical models of a variety of musculoskeletal conditions. Histological assessment relies on scoring systems that requir...

    Authors: Maxwell A. Konnaris, Matthew Brendel, Mark Alan Fontana, Miguel Otero, Lionel B. Ivashkiv, Fei Wang and Richard D. Bell
    Citation: Arthritis Research & Therapy 2022 24:68
  22. The objective of this study was to develop and validate a prediction model for renal urate underexcretion (RUE) in male gout patients.

    Authors: Mingshu Sun, Wenyan Sun, Xuetong Zhao, Zhiqiang Li, Nicola Dalbeth, Aichang Ji, Yuwei He, Hongzhu Qu, Guangmin Zheng, Lidan Ma, Jiayi Wang, Yongyong Shi, Xiangdong Fang, Haibing Chen, Tony R. Merriman and Changgui Li
    Citation: Arthritis Research & Therapy 2022 24:67
  23. Trabecular bone texture (TBT) analysis has been identified as an imaging biomarker that provides information on trabecular bone changes due to knee osteoarthritis (KOA). In parallel with the improvement in med...

    Authors: Ahmad Almhdie-Imjabbar, Khac-Lan Nguyen, Hechmi Toumi, Rachid Jennane and Eric Lespessailles
    Citation: Arthritis Research & Therapy 2022 24:66
  24. Diagnosing patients with giant cell arteritis (GCA) remains difficult. Due to its non-specific symptoms, it is challenging to identify GCA in patients presenting with symptoms of polymyalgia rheumatica (PMR), ...

    Authors: Yannick van Sleen, Philip Therkildsen, Berit Dalsgaard Nielsen, Kornelis S. M. van der Geest, Ib Hansen, Peter Heeringa, Marcel D. Posthumus, Maria Sandovici, Erik J. M. Toonen, Jannik Zijlstra, Annemieke M. H. Boots, Ellen-Margrethe Hauge and Elisabeth Brouwer
    Citation: Arthritis Research & Therapy 2022 24:65
  25. Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients. While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractil...

    Authors: H. Mark Kenney, Chia-Lung Wu, Alayna E. Loiselle, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz
    Citation: Arthritis Research & Therapy 2022 24:64
  26. Osteoarthritis is a degenerative disease of the knee that affects 250 million people worldwide. Due to the rising incidence of knee replacement and revision surgery, there is a need for a nonsurgical treatment...

    Authors: Kelly A. Kimmerling, Andreas H. Gomoll, Jack Farr and Katie C. Mowry
    Citation: Arthritis Research & Therapy 2022 24:63
  27. To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) in patients with idiopathic inf...

    Authors: Antonella Notarnicola, Charlotta Preger, Susanna L. Lundström, Nuria Renard, Edvard Wigren, Eveline Van Gompel, Angeles S. Galindo-Feria, Helena Persson, Maryam Fathi, Johan Grunewald, Per-Johan Jakobsson, Susanne Gräslund, Ingrid E. Lundberg and Cátia Fernandes-Cerqueira
    Citation: Arthritis Research & Therapy 2022 24:62
  28. Treatment of difficult-to-treat rheumatoid arthritis (D2T RA) is one of the greatest unmet needs in rheumatology. This study aims to find out preferable treatment options for a group of D2T RA patients who are...

    Authors: Sae Ochi, Koshiro Sonomoto, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:61
  29. Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly seen in the elderly that affects the whole “organ” including cartilage, subchondral bone, synovium, and muscles. An incre...

    Authors: Chong-Jie Wu, Ri-Xu Liu, Song-Wei Huan, Wang Tang, Yu-Kai Zeng, Jun-Cheng Zhang, Jie Yang, Zhen-Yan Li, Ying Zhou, Zhen-Gang Zha, Huan-Tian Zhang and Ning Liu
    Citation: Arthritis Research & Therapy 2022 24:59
  30. This study aimed to explore the clinical features of gout in adult patients with glycogen storage disease type Ia (GSD Ia).

    Authors: Na Xu, Xinxin Han, Yun Zhang, Xiaoming Huang, Weiguo Zhu, Min Shen, Wen Zhang, Chen Jialin, Min Wei, Zhengqing Qiu and Xuejun Zeng
    Citation: Arthritis Research & Therapy 2022 24:58
  31. TNF-α inhibitors are widely used in rheumatoid arthritis (RA) with varying success. Response to TNF-α inhibition may reflect the evolution of rheumatoid inflammation through fluctuating stages of TNF-α depende...

    Authors: Melanie J. Millier, Niamh C. Fanning, Christopher Frampton, Lisa K. Stamp and Paul A. Hessian
    Citation: Arthritis Research & Therapy 2022 24:57
  32. Rheumatoid arthritis (RA) is characterized by increased cardiovascular (CV) mortality. CV events are particularly high in patients with RA-specific autoimmunity, including rheumatoid factor (RF) and anti-citru...

    Authors: Hélène Gouze, Philippe Aegerter, Roula Said-Nahal, Marie Zins, Marcel Goldberg, Guillaume Morelle, Georg Schett, Maxime Breban and Maria Antonietta D’Agostino
    Citation: Arthritis Research & Therapy 2022 24:56
  33. Treatments used for rheumatoid arthritis (RA) are under investigation for their efficacy to prevent RA in at risk groups. It is therefore important to understand treatment preferences of those at risk. We syst...

    Authors: Gwenda Simons, Joshua Caplan, Rachael L. DiSantostefano, Jorien Veldwijk, Matthias Englbrecht, Karin Schölin Bywall, Ulrik Kihlbom, Karim Raza and Marie Falahee
    Citation: Arthritis Research & Therapy 2022 24:55
  34. Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone disease for which a lack of bacterial involvement is a key diagnostic feature to distinguish it from other symptomatically rela...

    Authors: Philipp Rausch, Meike Hartmann, John F. Baines and Philipp von Bismarck
    Citation: Arthritis Research & Therapy 2022 24:54
  35. To further improve rheumatoid arthritis (RA) treatment, it is necessary to understand each RA patient’s satisfaction and to identify the factors affecting their satisfaction. Despite the rise in medical costs ...

    Authors: Toshifumi Fujiwara, Masakazu Kondo, Hisakata Yamada, Akihisa Haraguchi, Kenjiro Fujimura, Koji Sakuraba, Satoshi Kamura, Jun-ichi Fukushi, Hisaaki Miyahara, Yasushi Inoue, Tomomi Tsuru, Toshihide Shuto, Seiji Yoshizawa, Eiichi Suematsu, Tomoya Miyamura, Masahiro Ayano…
    Citation: Arthritis Research & Therapy 2022 24:53
  36. Corticosteroid injection for knee osteoarthritis is limited by its modest duration of treatment effect. The liposome formulation of dexamethasone sodium phosphate (TLC599) was developed for the sustained relie...

    Authors: David J. Hunter, Chi-Ching Chang, James Cheng-Chung Wei, Hsiao-Yi Lin, Carl Brown, Tien-Tzu Tai, Chih-Feng Wu, Wing Chia-Ming Chuang and Sheue-Fang Shih
    Citation: Arthritis Research & Therapy 2022 24:52
  37. Although factors initiating the inflammatory response to monosodium urate crystals have been identified, the role of the gut microbiota and their metabolites on gout remains unknown. This study aimed to invest...

    Authors: Han-Ki Park and Sang Jin Lee
    Citation: Arthritis Research & Therapy 2022 24:51
  38. Systemic sclerosis (SSc), an autoimmune disease with unknown etiology and pathogenesis, is characterized by abnormal autoimmunity, vascular dysfunction, and progressive fibrosis of skin and organs. Studies hav...

    Authors: Zhuotong Zeng, Yaoyao Wang, Yangfan Xiao, Jie Zheng, Ruizhen Liu, Xinglan He, Jiangfan Yu, Bingsi Tang, Xiangning Qiu, Rui Tang, Yaqian Shi and Rong Xiao
    Citation: Arthritis Research & Therapy 2022 24:50
  39. Takayasu arteritis (TAK) is a chronic granulomatous large vessel vasculitis with multiple immune cells involved. Chemokines play critical roles in recruitment and activation of immune cells. This study aimed t...

    Authors: Xiufang Kong, Sifan Wu, Xiaojuan Dai, Wensu Yu, Jinghua Wang, Ying Sun, Zongfei Ji, Lingying Ma, Xiaomin Dai, Huiyong Chen, Lili Ma and Lindi Jiang
    Citation: Arthritis Research & Therapy 2022 24:49
  40. Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance and imbalance of immune cell subsets. Natural killer (NK) cells contribute to regulate both the innate and adaptive immune respon...

    Authors: Zhimin Lu, Yao Tian, Ziran Bai, Jiaqing Liu, Yan Zhang, Jingjing Qi, Minli Jin, Jie Zhu and Xia Li
    Citation: Arthritis Research & Therapy 2022 24:48
  41. Drug-free remission is a desirable goal in rheumatoid arthritis (RA) for both patients and clinicians. The aim of this post hoc analysis was to investigate whether clinical and magnetic resonance imaging (MRI)...

    Authors: Harris A. Ahmad, Joshua F. Baker, Philip G. Conaghan, Paul Emery, Thomas W. J. Huizinga, Yedid Elbez, Subhashis Banerjee and Mikkel Østergaard
    Citation: Arthritis Research & Therapy 2022 24:47
  42. Treatment goals for patients with systemic lupus erythematosus (SLE) include minimising disease activity and reducing the risk of flares. Although belimumab is effective at reducing disease activity and risk o...

    Authors: Sang-Cheol Bae, Damon L. Bass, Myron Chu, Paula Curtis, Richard Dimelow, Laurence Harvey, Beulah Ji, Regina Kurrasch, Saima Muzaffar, Raj Punwaney, David A. Roth, Yeong-Wook Song, Wendy Xie and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2022 24:46
  43. Synovial fibroblasts (SFs) in rheumatoid arthritis (RA) and osteoarthritis (OA) play biphasic roles in joint destruction and regeneration of bone/cartilage as mesenchymal stem cells (MSCs). Although MSCs contr...

    Authors: Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi and Shinsuke Yasuda
    Citation: Arthritis Research & Therapy 2022 24:45
  44. Abnormal cartilage calcification is one of the pathological changes of temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies have reported that exosomes can regulate the formation of abnormal calci...

    Authors: Qian Liu, Ruoxin Wang, Shujie Hou, Feng He, Yuanjun Ma, Tao Ye, Shibin Yu, Hongwei Chen, Helin Wang and Mian Zhang
    Citation: Arthritis Research & Therapy 2022 24:44
  45. During treatment with immune checkpoint inhibitors (ICI) such as the anti-PD-1 antibody pembrolizumab, half of patients with pre-existing inflammatory arthritis experience disease flares. The underlying immuno...

    Authors: Anne Sofie Sørensen, Morten Nørgaard Andersen, Kristian Juul-Madsen, Amalie Dyrelund Broksø, Cæcilie Skejø, Henrik Schmidt, Thomas Vorup-Jensen and Tue Wenzel Kragstrup
    Citation: Arthritis Research & Therapy 2022 24:43
  46. Based on clinical and genetic associations, axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) are suspected to have a linked pathogenesis. Gut dysbiosis, intrinsic to IBD, has also been obse...

    Authors: Jonas Sagard, Tor Olofsson, Elisabeth Mogard, Jan Marsal, Kristofer Andréasson, Mats Geijer, Lars Erik Kristensen, Elisabet Lindqvist and Johan K. Wallman
    Citation: Arthritis Research & Therapy 2022 24:42
  47. Hepatitis C virus (HCV) is the main etiology of cryoglobulinemia with mortality around 25%. Little is known on the changes in cryoglobulinemia mortality after the introduction of direct-acting antivirals (DAA)...

    Authors: Qianyu Guo, Jinfang Gao, Jiaoniu Duan, Ruihong Hou, Tsung-Hsueh Lu and Liyun Zhang
    Citation: Arthritis Research & Therapy 2022 24:41
  48. Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. We sought to identify serum cytokine signatures that risk stratify SSc...

    Authors: Kathleen D. Kolstad, Avani Khatri, Michele Donato, Sarah E. Chang, Shufeng Li, Virginia D. Steen, Paul J. Utz, Purvesh Khatri and Lorinda Chung
    Citation: Arthritis Research & Therapy 2022 24:39

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