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  1. Systemic sclerosis (SSc) is associated with a variability of mortality rates in the literature.

    Authors: Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue and Gregory Pugnet
    Citation: Arthritis Research & Therapy 2021 23:295
  2. The use of interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor as a treatment for the inflammatory joint disease is a promising method. However, its underlying mechanism in osteoarthritis (OA) remains...

    Authors: Muzhe Li, Huiyun Li, Xun Ran, Han Yin, Xuling Luo and Zhiwei Chen
    Citation: Arthritis Research & Therapy 2021 23:294
  3. Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified.

    Authors: Hiroki Mukoyama, Mirei Shirakashi, Nozomi Tanaka, Takeshi Iwasaki, Toshiki Nakajima, Hideo Onizawa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Masao Tanaka, Akio Morinobu and Hajime Yoshifuji
    Citation: Arthritis Research & Therapy 2021 23:293
  4. Humidity was an unfavorable factor for patients with rheumatoid arthritis (RA). RA disease activity was severe in high humidity conditions. However, there is no evidence to demonstrate the effects of humidity ...

    Authors: Mingzhu Wang, Jiao Chen, Xiaoying Lin, Lin Huang, Haichang Li, Chengping Wen and Zhixing He
    Citation: Arthritis Research & Therapy 2021 23:292
  5. We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-...

    Authors: Yogita Ghodke-Puranik, Zhongbo Jin, Kip D. Zimmerman, Hannah C. Ainsworth, Wei Fan, Mark A. Jensen, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Carl D. Langefeld and Timothy B. Niewold
    Citation: Arthritis Research & Therapy 2021 23:290
  6. Sjögren’s syndrome is a systemic autoimmune disease characterized by immune cells predominantly infiltrating the exocrine glands and frequently forming ectopic lymphoid structures. These structures drive a loc...

    Authors: Estelle Gerossier, Saba Nayar, Sylvie Froidevaux, Charlotte G. Smith, Celine Runser, Valentina Iannizzotto, Enrico Vezzali, Gabin Pierlot, Ulrich Mentzel, Mark J. Murphy, Marianne M. Martinic and Francesca Barone
    Citation: Arthritis Research & Therapy 2021 23:289
  7. Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA ...

    Authors: Bei Xu, Guanhua Xu, Ye Yu and Jin Lin
    Citation: Arthritis Research & Therapy 2021 23:288
  8. Osteoarthritis (OA) subsequent to acute joint injury accounts for a significant proportion of all arthropathies. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor ce...

    Authors: Lixia Zhang, Cameron L. Kirkwood, Jiho Sohn, Ashley Lau, Mary Bayers-Thering, Supinder Kour Bali, Sridhar Rachala, John M. Marzo, Mark J. Anders, Frank Beier and Keith L. Kirkwood
    Citation: Arthritis Research & Therapy 2021 23:287
  9. Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-I...

    Authors: Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen and Gabriel Mbalaviele
    Citation: Arthritis Research & Therapy 2021 23:286
  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren
    Citation: Arthritis Research & Therapy 2021 23:285

    The original article was published in Arthritis Research & Therapy 2021 23:269

  11. This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering alg...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Hoon-Suk Cha, Eun-Mi Koh and Jaejoon Lee
    Citation: Arthritis Research & Therapy 2021 23:284
  12. We have recently demonstrated that serum CCL20 levels positively correlate with mean pulmonary arterial pressure in patients with systemic sclerosis (SSc). Considering a proangiogenic effect of CCL20 on endoth...

    Authors: Tetsuya Ikawa, Takuya Miyagawa, Yuki Fukui, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Yuta Norimatsu, Yusuke Watanabe, Ayumi Yoshizaki, Shinichi Sato and Yoshihide Asano
    Citation: Arthritis Research & Therapy 2021 23:283
  13. Authors: Francesca Ometto, Augusta Ortolan, Davide Farber, Mariagrazia Lorenzin, Giulia Dellamaria, Giacomo Cozzi, Marta Favero, Romina Valentini, Andrea Doria and Roberta Ramonda
    Citation: Arthritis Research & Therapy 2021 23:282

    The original article was published in Arthritis Research & Therapy 2021 23:219

  14. To assess the first-year features of patients with chronic nonbacterial osteomyelitis (CNO).

    Authors: Christiane Reiser, Jens Klotsche, Anton Hospach, Rainer Berendes, Anja Schnabel, Annette F. Jansson, Markus Hufnagel, Nadine Grösch, Martina Niewerth, Kirsten Minden and Hermann Girschick
    Citation: Arthritis Research & Therapy 2021 23:281
  15. Anterior cruciate ligament (ACL) and meniscus tears are common knee injuries. Despite the high rate of post-traumatic osteoarthritis (PTOA) following these injuries, the contributing factors remain unclear. In...

    Authors: Sophia Y. Kim-Wang, Abigail G. Holt, Alyssa M. McGowan, Stephanie T. Danyluk, Adam P. Goode, Brian C. Lau, Alison P. Toth, Jocelyn R. Wittstein, Louis E. DeFrate, John S. Yi and Amy L. McNulty
    Citation: Arthritis Research & Therapy 2021 23:280
  16. Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of varia...

    Authors: Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning and Xu-jie Zhou
    Citation: Arthritis Research & Therapy 2021 23:279
  17. Clinical trials show intensive treatment to induce remission is effective in patients with highly active rheumatoid arthritis (RA). The TITRATE trial showed that the benefits of intensive treatment also extend...

    Authors: Sook Yan Lee, Fowzia Ibrahim, Brian D. M. Tom, Elena Nikiphorou, Frances M. K. Williams, Heidi Lempp and David L. Scott
    Citation: Arthritis Research & Therapy 2021 23:278
  18. Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a...

    Authors: Caining Wen, Limei Xu, Xiao Xu, Daping Wang, Yujie Liang and Li Duan
    Citation: Arthritis Research & Therapy 2021 23:277
  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy and Khaled A. Elsaid
    Citation: Arthritis Research & Therapy 2021 23:276

    The original article was published in Arthritis Research & Therapy 2021 23:241

  20. To clarify the frequency and outcome of patients with systemic lupus erythematosus (SLE) who achieved the clinical state as serologically active clinically quiescent (SACQ) and to identify factors associated w...

    Authors: Hong Huang, Lin Mu, Zhuoli Zhang, Dai Gao, Yanjie Hao and Wei Zhou
    Citation: Arthritis Research & Therapy 2021 23:275
  21. Identification of predictive clinical factors of long-term treatment response may contribute to improved management of non-radiographic axSpA (nr-axSpA) patients. This analysis aims to identify whether any bas...

    Authors: Walter P. Maksymowych, Thomas Kumke, Simone E. Auteri, Bengt Hoepken, Lars Bauer and Martin Rudwaleit
    Citation: Arthritis Research & Therapy 2021 23:274
  22. Central nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with rheumatoid arthritis (RA). However, it remains unclear how the periph...

    Authors: Takayuki Matsushita, Kazuhiro Otani, Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka and Fusao Kato
    Citation: Arthritis Research & Therapy 2021 23:273
  23. Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor ...

    Authors: H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes and F. A. van Gaalen
    Citation: Arthritis Research & Therapy 2021 23:272
  24. Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, reports of its use and subsequent fatal arrhythmias in patients with coronavirus...

    Authors: Elizabeth Park, Jon T. Giles, Thania Perez-Recio, Paloma Pina, Christopher Depender, Yevgeniya Gartshteyn, Anca D. Askanase, Joan Bathon and Laura Geraldino-Pardilla
    Citation: Arthritis Research & Therapy 2021 23:271
  25. Self-efficacy, or patients’ confidence in their ability to control disease and its consequences, was recently prioritised in EULAR recommendations for inflammatory arthritis self-management strategies. However...

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren
    Citation: Arthritis Research & Therapy 2021 23:269

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:285

  26. A considerable proportion of patients with rheumatoid arthritis (RA) also suffer from hand osteoarthritis (OA). We here assess the association between conventional synthetic (cs) and biological (b) disease-mod...

    Authors: C. A. Lechtenboehmer, T. Burkard, S. Reichenbach, U. A. Walker, A. M. Burden and T. Hügle
    Citation: Arthritis Research & Therapy 2021 23:267
  27. Connective tissue growth factor (CTGF)-induced angiogenesis is a crucial factor in rheumatoid arthritis (RA), but CTGF-interacting protein and related molecular mechanism of their interaction have not been ful...

    Authors: Guoyu Yin, Chenglin Yang, Gan Wu, Xinxin Yu, Qingqing Tian, Daoxing Chen, Ben Cao, Lin Zhao, Nannan Xu, Shengwei Jin, Wei Zhang and Jianguang Wang
    Citation: Arthritis Research & Therapy 2021 23:266
  28. The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of treatment response. Annexin A2, an inflammation-assoc...

    Authors: Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham and Samuel Achilefu
    Citation: Arthritis Research & Therapy 2021 23:265
  29. Infectious disease is an increasing threat to patients with systemic lupus erythematosus (SLE); however, the long-term outcome in critically ill septic patients with SLE remains unclear, and we aimed to addres...

    Authors: Hsin-Hua Chen, Hsian-Min Chen, Yi-Ming Chen, Yi-Hsing Chen, Ching-Heng Lin and Wen-Cheng Chao
    Citation: Arthritis Research & Therapy 2021 23:264
  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: R. E. Costello, J. H. Humphreys, J. C. Sergeant, M. Haris, F. Stirling, K. Raza, D. van Schaardenburg and Ian N. Bruce
    Citation: Arthritis Research & Therapy 2021 23:263

    The original article was published in Arthritis Research & Therapy 2021 23:210

  31. The identification of patients with knee osteoarthritis (OA) likely to progress rapidly in terms of structure is critical to facilitate the development of disease-modifying drugs.

    Authors: Jean-Baptiste Schiratti, Rémy Dubois, Paul Herent, David Cahané, Jocelyn Dachary, Thomas Clozel, Gilles Wainrib, Florence Keime-Guibert, Agnes Lalande, Maria Pueyo, Romain Guillier, Christine Gabarroca and Philippe Moingeon
    Citation: Arthritis Research & Therapy 2021 23:262
  32. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis, with a higher incidence of malignancy. The aim of this study is to identify biomarkers for predicting mali...

    Authors: Yuzhou Gan, Yi Sun, Jiayang Jin, Yifan Wang, Jiali Chen, Yukchiu Chung, Xue Li and Hua Ye
    Citation: Arthritis Research & Therapy 2021 23:261
  33. To identify potential biomarkers to distinguish familial Mediterranean fever (FMF) from sepsis.

    Authors: Tomohiro Koga, Kaori Furukawa, Kiyoshi Migita, Shimpei Morimoto, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Yushiro Endo, Remi Sumiyoshi, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Takahiro Maeda, Akihiro Yachie…
    Citation: Arthritis Research & Therapy 2021 23:260
  34. Serum proteins can be readily assessed during routine clinical care. However, it is unclear to what extent serum proteins reflect the molecular dysregulations of peripheral blood cells (PBCs) or affected end-o...

    Authors: Victor Farutin, Elma Kurtagic, Joël R. Pradines, Ishan Capila, Maureen D. Mayes, Minghua Wu, Anthony M. Manning and Shervin Assassi
    Citation: Arthritis Research & Therapy 2021 23:259
  35. Patients with rheumatoid arthritis (RA) are almost twice as likely to develop cardiovascular disease (CVD) as those without. However, traditional CVD risks have been shown to underperform in RA patients; thus,...

    Authors: Seungwoo Han, Na-Ri Kim, Jong-Wan Kang, Jung-Su Eun and Young-Mo Kang
    Citation: Arthritis Research & Therapy 2021 23:258
  36. Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease which has focal lymphocytic infiltration including a majority of CD4+ T cells. This study was to investigate the correlation of periphe...

    Authors: Qi Wang, Nan Che, Chengyin Lu, Xiaoxuan Sun, Yanyan Wang, Qiang Wang, Wenfeng Tan, Lanlan Zhou, Xiaojun Zhang, Dong Xu, Lei Gu and Miaojia Zhang
    Citation: Arthritis Research & Therapy 2021 23:257
  37. Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder. Diagnosing AOSD can be challenging, as disease presentation and clinical course are highly heterogeneous. For unclear reasons, a few...

    Authors: Anaïs Wahbi, Benoît Tessoulin, Cédric Bretonnière, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Sophie Georgin-Lavialle, Mohamed Hamidou…
    Citation: Arthritis Research & Therapy 2021 23:256
  38. Authors: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina…
    Citation: Arthritis Research & Therapy 2021 23:255

    The original article was published in Arthritis Research & Therapy 2021 23:239

  39. Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analy...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh and Hoon-Suk Cha
    Citation: Arthritis Research & Therapy 2021 23:254
  40. The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA.

    Authors: Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangelo and Adam R. Konopka
    Citation: Arthritis Research & Therapy 2021 23:253

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:20

  41. The occurrence of health events preceding a psoriatic arthritis (PsA) diagnosis may serve as predictors of diagnosis. We sought to assess patients’ real-world experiences in obtaining a PsA diagnosis.

    Authors: Alexis Ogdie, Martin Rozycki, Theresa Arndt, Cheng Shi, Nina Kim and Peter Hur
    Citation: Arthritis Research & Therapy 2021 23:252
  42. Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies re...

    Authors: Yanlin Cao, Yenan Zhan, Sujun Qiu, Zhong Chen, Kaiqin Gong, Songjia Ni and Yang Duan
    Citation: Arthritis Research & Therapy 2021 23:251
  43. Patients with autoimmune diseases often present with olfactory impairment. The aim of the study was to assess the olfactory functions of patients with primary Sjögren’s syndrome and to correlate these findings...

    Authors: Xue Xu, Linyu Geng, Chen Chen, Wentao Kong, Baojie Wen, Wei Kong, Siwen Chen, Huayong Zhang, Jun Liang and Lingyun Sun
    Citation: Arthritis Research & Therapy 2021 23:250
  44. Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is ass...

    Authors: Sang Jin Lee, Jung Su Eun, Min Jung Kim, Yeong Wook Song and Young Mo Kang
    Citation: Arthritis Research & Therapy 2021 23:249
  45. REFLECTIONS B538–02 is a randomized, double-blind comparative study of the adalimumab (ADL) biosimilar PF-06410293, (ADL-PF), and reference ADL sourced from the European Union (ADL-EU) in patients with active ...

    Authors: Roy M. Fleischmann, Daniel F. Alvarez, Amy E. Bock, Carol Cronenberger, Ivana Vranic, Wuyan Zhang and Rieke Alten
    Citation: Arthritis Research & Therapy 2021 23:248
  46. In patients with axial spondyloarthritis (axSpA), monocytes show a pre-activated phenotype. Gut inflammation is a trigger of monocyte activation and may also affect their development in the bone marrow (BM). A...

    Authors: Fabian Karow, Biljana Smiljanovic, Joachim R. Grün, Denis Poddubnyy, Fabian Proft, Alice Talpin, Christophe Hue, Anne Boland, Jean-François Deleuze, Henri-Jean Garchon, Ilkay Ergenç, Ann-Sophie De Craemer, Ulrike Erben, Thomas Häupl, Dirk Elewaut, Maxime Breban…
    Citation: Arthritis Research & Therapy 2021 23:246

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