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  1. Individual fatty acids (FAs) and their derivatives (lipid mediators) with pro-inflammatory or dual anti-inflammatory and pro-resolving properties have potential to influence the health of joint tissues. Osteoa...

    Authors: Anne-Mari Mustonen, Nina Lehmonen, Tommi Paakkonen, Marja Raekallio, Reijo Käkelä, Tytti Niemelä, Anna Mykkänen, Sanna P. Sihvo and Petteri Nieminen
    Citation: Arthritis Research & Therapy 2023 25:39
    Content type: Research Published on:

  2. Patients with systemic sclerosis (SSc) are frequently affected by iron deficiency, particularly those with pulmonary hypertension (PH). The first data indicate the prognostic importance of hypochromic red cell...

    Authors: Panagiota Xanthouli, Ojan Gordjani, Nicola Benjamin, Satenik Harutyunova, Benjamin Egenlauf, Alberto M. Marra, Simon Haas, Nicklas Milde, Norbert Blank, Hanns-Martin Lorenz, Christoph Fiehn, Silvia Ulrich, Oliver Distler, Ekkehard Grünig and Christina A. Eichstaedt
    Citation: Arthritis Research & Therapy 2023 25:38
    Content type: Research Published on:

  3. Rheumatoid arthritis (RA) occurs across the globe in different ethnic populations. Most RA patients harbor anti-modified protein antibodies (AMPA); however, it is unclear whether differences exist in autoantib...

    Authors: Emma C. de Moel, Leendert A. Trouw, Chikashi Terao, Nimmisha Govind, Mohammed Tikly, Hani El-Gabalawy, Irene Smolik, Holger Bang, Tom W. J. Huizinga, René E. M. Toes and Diane van der Woude
    Citation: Arthritis Research & Therapy 2023 25:37
    Content type: Research Published on:

  4. The mechanism of humoral immunity to Takayasu arteritis (TAK) is not clear. In our study, we aimed to investigate the correlation between immunoglobulins and disease activity and the relationship between immun...

    Authors: Yanqiu Guo, Juan Du, Taotao Li, Na Gao, Shiyu Yang, Yaxin Zhang and Lili Pan
    Citation: Arthritis Research & Therapy 2023 25:36
    Content type: Research Published on:

  5. This study aimed to evaluate the effectiveness of metformin versus placebo in overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of inflammatory mediators and apoptotic prote...

    Authors: Nahid Alimoradi, Mohammad Tahami, Negar Firouzabadi, Elham Haem and Amin Ramezani
    Citation: Arthritis Research & Therapy 2023 25:35
    Content type: Research Published on:

  7. Clonal haematopoiesis of indeterminate potential (CHIP) is a predisposition to haematological malignancy whose relationship with chronic inflammatory diseases, such as cardiovascular diseases, has been highlig...

    Authors: Jihye Park, Hongyul An, Jiwoo Lim, I Seul Park, Mi Hyun Kim, Ji Hyung Kim, Seung Won Kim, Young Il Koh, Eun Young Lee and Jae Hee Cheon
    Citation: Arthritis Research & Therapy 2023 25:33
    Content type: Research Published on:

  8. We aimed to investigate the gut microbiota of patients with established rheumatoid arthritis (RA) who have been managed with disease-modifying anti-rheumatic drugs (DMARDs) for a long time. We focused on facto...

    Authors: Jung Hee Koh, Eun Ha Lee, Kwang Hyun Cha, Cheol-Ho Pan, Donghyun Kim and Wan-Uk Kim
    Citation: Arthritis Research & Therapy 2023 25:32
    Content type: Research Published on:

  9. We sought to identify features that distinguish osteoarthritis (OA) and rheumatoid arthritis (RA) hematoxylin and eosin (H&E)-stained synovial tissue samples.

    Authors: Bella Mehta, Susan Goodman, Edward DiCarlo, Deanna Jannat-Khah, J. Alex B. Gibbons, Miguel Otero, Laura Donlin, Tania Pannellini, William H. Robinson, Peter Sculco, Mark Figgie, Jose Rodriguez, Jessica M. Kirschmann, James Thompson, David Slater, Damon Frezza…
    Citation: Arthritis Research & Therapy 2023 25:31
    Content type: Research Published on:

  10. Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1β and downregulation of IL-1 receptor antagonist, the mechanism of which remains to be fully ...

    Authors: Viola Klück, Georgiana Cabău, Linda Mies, Femke Bukkems, Liesbeth van Emst, René Bakker, Arjan van Caam, Tania O. Crişan and Leo A. B. Joosten
    Citation: Arthritis Research & Therapy 2023 25:30
    Content type: Research Published on:

  11. To evaluate how radiographic damage, overall and measured as joint space narrowing score (JSNS) and erosion score (ES), as well as other clinical and laboratory measures, relate to disability and pain in early...

    Authors: Anna Eberhard, Emil Rydell, Kristina Forslind, Stefan Bergman, Thomas Mandl, Tor Olofsson, Lennart T. H. Jacobsson and Carl Turesson
    Citation: Arthritis Research & Therapy 2023 25:29
    Content type: Research Published on:

  12. Ectopic ossification is an important cause of disability in patients with ankylosing spondylitis (AS). Whether fibroblasts can transdifferentiate into osteoblasts and contribute to ossification remains unknown...

    Authors: Qianmei Jin, Yaoyang Liu, Zhiguo Zhang, Xingzhu Wen, Ziqiang Chen, Haijun Tian, Zijian Kang, Xin Wu and Huji Xu
    Citation: Arthritis Research & Therapy 2023 25:28
    Content type: Research Published on:

  13. Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still believed to be a mecha...

    Authors: Loay A. Salman, Ghalib Ahmed, Stephanie G. Dakin, Benjamin Kendrick and Andrew Price
    Citation: Arthritis Research & Therapy 2023 25:27
    Content type: Review Published on:

  14. Systemic lupus erythematosus (SLE) is heterogeneous in organ involvement and disease severity, presenting a broad clinical phenotype. Systemic type I interferon (IFN) activity has been shown to be associated w...

    Authors: Kazusa Miyachi, Taro Iwamoto, Shotaro Kojima, Tomoaki Ida, Junya Suzuki, Takuya Yamamoto, Norihiro Mimura, Takahiro Sugiyama, Shigeru Tanaka, Shunsuke Furuta, Kei Ikeda, Kotaro Suzuki, Timothy B. Niewold and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2023 25:26
    Content type: Research Published on:

  15. Anti-citrullinated protein/peptide antibodies (ACPAs) are present in patients at onset and have important pathogenic roles during the course of rheumatoid arthritis (RA). The characteristics of several molecul...

    Authors: Akio Umemoto, Takeshi Kuwada, Koichi Murata, Masahiro Shiokawa, Sakiko Ota, Yoshiki Murotani, Akihiro Itamoto, Kohei Nishitani, Hiroyuki Yoshitomi, Takayuki Fujii, Akira Onishi, Hideo Onizawa, Kosaku Murakami, Masao Tanaka, Hiromu Ito, Hiroshi Seno…
    Citation: Arthritis Research & Therapy 2023 25:25
    Content type: Research Published on:

  17. To determine the diagnostic discriminant validity between large vessel giant cell arteritis (LV-GCA) and atherosclerosis using ultrasound (US) intima-media thickness (IMT) measurements.

    Authors: Irene Monjo-Henry, Elisa Fernández-Fernández, José María Mostaza, Carlos Lahoz, Juan Molina-Collada and Eugenio de Miguel
    Citation: Arthritis Research & Therapy 2023 25:23
    Content type: Research Published on:

  18. To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoart...

    Authors: Christian S. Thudium, Amalie Engstrøm, Anne-Christine Bay-Jensen, Peder Frederiksen, Nuria Jansen, Arjan De Zwart, Marike van der Leeden, Joost Dekker, Willem Lems, Leo Roorda, Willem Evert van Spil and Martin Van der Esch
    Citation: Arthritis Research & Therapy 2023 25:22
    Content type: Research Published on:

  19. Elevated levels of interferons (IFNs) are a characteristic feature of systemic autoimmune rheumatic diseases (SARDs) and may be useful in predicting impending symptomatic progression in anti-nuclear antibody-p...

    Authors: Sonya T. Kim, Carolina Muñoz-Grajales, Shannon E. Dunn, Raphael Schneider, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad, Dennisse Bonilla, Eshetu G. Atenafu, Linda T. Hiraki, Arthur Bookman and Joan Wither
    Citation: Arthritis Research & Therapy 2023 25:21
    Content type: Research Published on:

  20. Previous studies have shown systemic lupus erythematosus (SLE) patients had a significantly higher prevalence of thyroid diseases and hypothyroidism than matched controls, and some case reports showed SLE may ...

    Authors: Hong-Ci Lin, Hsu-Min Chang, Yao-Min Hung, Renin Chang, Hsin-Hua Chen and James Cheng-Chung Wei
    Citation: Arthritis Research & Therapy 2023 25:20
    Content type: Research Published on:

  21. Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogen...

    Authors: Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu and Peng Xu
    Citation: Arthritis Research & Therapy 2023 25:19
    Content type: Research Published on:

  23. Although treatment options and algorithms for rheumatoid arthritis (RA) have improved remarkably in recent decades, there continues to be no definitive cure or pharmacologic intervention with reliable long-ter...

    Authors: H. Mark Kenney, Ronald W. Wood, Gabriel Ramirez, Richard D. Bell, Kiana L. Chen, Lindsay Schnur, Homaira Rahimi, Benjamin D. Korman, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz and Calvin L. Cole
    Citation: Arthritis Research & Therapy 2023 25:17
    Content type: Research Published on:

  24. People with dermatomyositis (DM) or polymyositis (PM) often die from cancer, pulmonary, cardiac complications, or infections. In such cases, DM or PM might not be designated as the underlying cause of death (...

    Authors: Pengyan Qiao, Qianyu Guo, Jinfang Gao, Dan Ma, Sumiao Liu, Xiang Gao, Tsung-Hsueh Lu and Liyun Zhang
    Citation: Arthritis Research & Therapy 2023 25:16
    Content type: Research Published on:

  25. The study of molecular mechanisms characterizing disease progression may be relevant to get insights into systemic sclerosis (SSc) pathogenesis and to intercept patients at very early stage. We aimed at invest...

    Authors: Chiara Bellocchi, Shervin Assassi, Marka Lyons, Maurizio Marchini, Chandra Mohan, Alessandro Santaniello and Lorenzo Beretta
    Citation: Arthritis Research & Therapy 2023 25:15
    Content type: Research Published on:

  26. Hip and knee osteoarthritis (HKOA) is a chronic disease characterized by joint pain that leads to reduced physical function and health-related quality of life (HRQoL). At present, no cure is available. Clinica...

    Authors: David G. Lopes, Daniela Costa, Eduardo B. Cruz, Nuno Mendonça, Ana Rita Henriques, Jaime Branco, Helena Canhão and Ana M. Rodrigues
    Citation: Arthritis Research & Therapy 2023 25:14
    Content type: Research Published on:

  27. To evaluate the safety, efficacy, and maternal and fetal outcomes of assisted reproductive therapy (ART) in systemic lupus erythematosus (SLE).

    Authors: Minxi Lao, Peiyin Dai, Guangxi Luo, Xing Yang, Miaoguan Peng, Yuyi Chen, Yanfeng Zhan, Zhongping Zhan and Dongying Chen
    Citation: Arthritis Research & Therapy 2023 25:13
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:18

  28. Systemic sclerosis is a rheumatoid disease best known for its fibrotic skin manifestations called scleroderma. Alternatively activated (M2-type) macrophages are normally involved in the resolution of inflammat...

    Authors: Ilari Mäki-Opas, Mari Hämäläinen, Eeva Moilanen and Morena Scotece
    Citation: Arthritis Research & Therapy 2023 25:12
    Content type: Research Published on:

  30. Lack of robust, feasible, and quantitative outcomes impedes Raynaud phenomenon (RP) clinical trials in systemic sclerosis (SSc) patients. Hyperspectral imaging (HSI) non-invasively measures oxygenated and deox...

    Authors: Shannon Teaw, Akash Gupta, Alyssa Williams, F. Perry Wilson, Brandon J. Sumpio, Bauer E. Sumpio and Monique Hinchcliff
    Citation: Arthritis Research & Therapy 2023 25:10
    Content type: Research Published on:

  32. Enthesitis represents one of the most important peripheral musculoskeletal manifestations in patients with axial spondyloarthritis (axSpA). However, studies specifically evaluating Achilles tendon enthesitis a...

    Authors: Clementina López-Medina, M. Ángeles Puche-Larrubia, Raquel Granados, Lourdes Ladehesa-Pineda, Desirée Ruiz-Vilchez, M. Carmen Ábalos-Aguilera, Pilar Font-Ugalde and Eduardo Collantes-Estévez
    Citation: Arthritis Research & Therapy 2023 25:8
    Content type: Research Published on:

  33. Hypertension is a common comorbidity of osteoarthritis (OA) with known autonomic dysregulation; thus, the autonomic nervous system may provide a shared underlying mechanism. The objective of this study was to ...

    Authors: Taylor D. Yeater, Jacob L. Griffith, Carlos J. Cruz, Folly M. Patterson, Jessica L. Aldrich and Kyle D. Allen
    Citation: Arthritis Research & Therapy 2023 25:7
    Content type: Research Published on:

  34. Platelet-rich plasma (PRP) therapy is increasingly popular to treat musculoskeletal diseases, including tendinopathies and osteoarthritis (OA). To date, it remains unclear to which extent PRP compositions are ...

    Authors: Marcel Niemann, Melanie Ort, Luis Lauterbach, Mathias Streitz, Andreas Wilhelm, Gerald Grütz, Florian N. Fleckenstein, Frank Graef, Antje Blankenstein, Simon Reinke, Ulrich Stöckle, Carsten Perka, Georg N. Duda, Sven Geißler, Tobias Winkler and Tazio Maleitzke
    Citation: Arthritis Research & Therapy 2023 25:6
    Content type: Research Published on:

  35. Behçet’s disease (BD) is a systemic inflammatory disease that involves various organs. The clinical manifestation-based diagnosis of BD is a time-consuming process, which makes it difficult to distinguish from...

    Authors: Soo Jin Park, Mi Jin Park, Sun Park, Eun-So Lee and Do Yup Lee
    Citation: Arthritis Research & Therapy 2023 25:5
    Content type: Research Published on:

  36. Immunoglobulin-G4-related disease (IgG4-RD) is a distinct systemic autoimmune-mediated disease manifesting as chronic inflammation and tissue fibrosis. Since the role of DNA methylation in the pathogenesis of ...

    Authors: Xunyao Wu, Anqi Wang, Mu Wang, Yu Peng, Yingying Chen, Jieqiong Li, Zheng Liu, Hui Lu, Jiaxin Zhou, Linyi Peng, Yan Zhao, Xiaofeng Zeng, Yunyun Fei and Wen Zhang
    Citation: Arthritis Research & Therapy 2023 25:4
    Content type: Research Published on:

  37. Osteoarthritis (OA) is a common and prevalent degenerative joint disease characterized by degradation of the articular cartilage. However, none of disease-modifying OA drugs is approved currently. Teriparatide...

    Authors: Guoqing Li, Su Liu, Huihui Xu, Yixiao Chen, Jiapeng Deng, Ao Xiong, Deli Wang, Jian Weng, Fei Yu, Liang Gao, Changhai Ding and Hui Zeng
    Citation: Arthritis Research & Therapy 2023 25:3
    Content type: Review Published on:

  38. Data on the association of vitamin D levels and clinical phenotype and disease activity in systemic lupus erythematosus (SLE) is controversial. Further, the optimal dose of oral vitamin D supplementation in SL...

    Authors: Chengappa Kavadichanda, Pratibha Singh, Supriya Maurya, Sneha Tota, Aberaame Kiroubagarin, Deepika Kounassegarane, Swathi Anand, Vir Singh Negi and Amita Aggarwal
    Citation: Arthritis Research & Therapy 2023 25:2
    Content type: Research Published on:

  39. Giant cell arteritis (GCA) is a primary large-vessel vasculitis (LVV) of unknown origin. Its management is a challenge due to the late onset of disease symptoms and frequent relapse; therefore, clarifying the ...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Hiroto Yoshida, Mayu Magi, Yoshihiro Matsumoto, Mariko Noguchi-Sasaki, Keiko Yoshimoto, Tsutomu Takeuchi and Yuko Kaneko
    Citation: Arthritis Research & Therapy 2023 25:1
    Content type: Research Published on:

  40. Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) homeostasis, aberrant chondrocyte...

    Authors: Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li and Bin Shen
    Citation: Arthritis Research & Therapy 2022 24:286
    Content type: Review Published on:

  41. Sugiyama et al. recently described in “Latent class analysis of 216 patients with adult-onset Still’s disease,” baseline characteristics, laboratory tests, treatment, relapse, and death of adult-onset Still’s ...

    Authors: Marion Delplanque, Arsène Mekinian and Sophie Georgin-Lavialle
    Citation: Arthritis Research & Therapy 2022 24:285
    Content type: Correspondence Published on:

  42. Lupus nephritis (LN) is the most common and serious complication of systemic lupus erythematosus (SLE). LN pathogenesis is not fully understood. Axl receptor tyrosine kinase is upregulated and contributes to t...

    Authors: Yuxuan Zhen, Yan Ren, Mario Medvedovic, David E. Adams, Diping Wang and Wen-Hai Shao
    Citation: Arthritis Research & Therapy 2022 24:284
    Content type: Research Published on:

  43. Psoriatic arthritis (PsA) patient data from two phase 3 secukinumab trials (FUTURE 1, 5) were analysed to quantify the prevalence and extent of pre-existing radiographic damage (RD) at baseline; investigate th...

    Authors: Philip Mease, Désirée van der Heijde, Bruce Kirkham, Georg Schett, Ana-Maria Orbai, Christopher Ritchlin, Joseph F. Merola, Luminita Pricop, David A. James, Xuan Zhu and Gregory Ligozio
    Citation: Arthritis Research & Therapy 2022 24:283
    Content type: Research Published on:

  44. The infrapatellar fat pad (IFP) is the largest adipose deposit in the knee; however, its contributions to the homeostasis of this organ remain undefined. To determine the influence of the IFP and its associate...

    Authors: Maryam F. Afzali, Lauren B. Radakovich, Madeline M. Sykes, Margaret A. Campbell, Kayley M. Patton, Joseph L. Sanford, Nicole Vigon, Ryan Ek, Gerardo E. Narez, Angela J. Marolf, Katie J. Sikes, Tammy L. Haut Donahue and Kelly S. Santangelo
    Citation: Arthritis Research & Therapy 2022 24:282
    Content type: Research Published on:

  45. Uncontrolled/refractory gout patients are recalcitrant/intolerant to oral urate-lowering therapies (ULTs), experiencing frequent gout flares, functionally limiting tophi, and low quality of life. Pegloticase l...

    Authors: John K. Botson, Katie Obermeyer, Brian LaMoreaux, Lin Zhao, Michael E. Weinblatt and Jeff Peterson
    Citation: Arthritis Research & Therapy 2022 24:281
    Content type: Research Published on:

  46. Interstitial lung disease, a common extra-articular complication of connective tissue disease, is characterized by progressive and irreversible pulmonary inflammation and fibrosis, which causes significant mor...

    Authors: Ziye Qu, Wencan Dou, Kexin Zhang, Lili Duan, Dongmei Zhou and Songlou Yin
    Citation: Arthritis Research & Therapy 2022 24:280
    Content type: Research Published on:

  47. In axial spondyloarthritis (axSpA) inflammation of the sacroiliac joints and spine is associated with local extracellular matrix (ECM) remodeling of affected tissues. We aimed to investigate the association of...

    Authors: Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møller, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2022 24:279
    Content type: Research Published on:

  48. In patients affected by connective tissue diseases (CTDs), the identification of wide autoantibody profiles may prove useful in early diagnosis, in the evaluation of prognosis (risk stratification), and in pre...

    Authors: Nicola Bizzaro, Danilo Villalta, Vittorio Bini, Paola Migliorini, Franco Franceschini, Silvia Piantoni, Emirena Garrafa, Valeria Riccieri, Antonella Fioravanti, Francesca Bellisai, Marilina Tampoia, Marco Fornaro, Florenzo Iannone, Anna Ghirardello, Margherita Zen, Boaz Palterer…
    Citation: Arthritis Research & Therapy 2022 24:278
    Content type: Research Published on:

  49. Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsa...

    Authors: Yue-Peng Jiang, Song Wang, Wei-Dong Lai, Xue-Qing Wu, Yan Jin, Zheng-Hao Xu, Aubin Moutal, Rajesh Khanna, Ki Duk Park, Zhi-Ming Shan, Cheng-Ping Wen and Jie Yu
    Citation: Arthritis Research & Therapy 2022 24:277
    Content type: Research Published on:

  50. To evaluate the effects of tumor necrosis factor inhibitors (TNFi), interleukin-6 receptor inhibitors (IL-6Ri), and Janus kinase inhibitors (JAKi) on hemoglobin (Hb) and C-reactive protein (CRP) levels in adul...

    Authors: Anthony S. Padula, Dimitrios A. Pappas, Stefano Fiore, Taylor S. Blachley, Kerri Ford, Kelechi Emeanuru and Joel M. Kremer
    Citation: Arthritis Research & Therapy 2022 24:276
    Content type: Research Published on:

    The Research to this article has been published in Arthritis Research & Therapy 2022 24:207

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